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CATH Superfamily 1.20.1250.20

MFS general substrate transporter like domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 81: Lactose permease

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Carbohydrate:proton symporter activity GO:0005351
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in).
 104 P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA)
(94 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 104 P02920 (/IPI) P02920 (/IPI) P02920 (/IPI) P02920 (/IPI) P02920 (/IPI) P02920 (/IPI) P02920 (/IPI) P02920 (/IPI) P02920 (/IPI) P02920 (/IPI)
(94 more)
Lactose:proton symporter activity GO:0015528
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in).
 104 P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA)
(94 more)
Lactose:proton symporter activity GO:0015528
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in).
 104 P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP)
(94 more)
Lactose binding GO:0030395
Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.
 104 P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA)
(94 more)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Carbohydrate transport GO:0008643
The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y.
 104 P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP) P02920 (/IMP)
(94 more)
Lactose transport GO:0015767
The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals.
 104 P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA)
(94 more)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 104 P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA)
(94 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 104 P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA)
(94 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 104 P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA)
(94 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 104 P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA) P02920 (/IDA)
(94 more)