The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 70: Solute carrier family 22 member 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Carnitine transmembrane transporter activity GO:0015226
Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
9 A0A0R4IMT8 (/IDA) O70594 (/IDA) O76082 (/IDA) Q9H015 (/IDA) Q9WTN6 (/IDA) Q9WTN6 (/IDA) Q9Z0E8 (/IDA) Q9Z0E8 (/IDA) Q9Z306 (/IDA)
Quaternary ammonium group transmembrane transporter activity GO:0015651
Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
6 O70594 (/IDA) O76082 (/IDA) Q9H015 (/IDA) Q9R141 (/IDA) Q9Z0E8 (/IDA) Q9Z0E8 (/IDA)
Carnitine transmembrane transporter activity GO:0015226
Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
4 O70594 (/IMP) O76082 (/IMP) Q9Z0E8 (/IMP) Q9Z0E8 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O70594 (/IPI) O76082 (/IPI) Q9H015 (/IPI)
Amino-acid betaine transmembrane transporter activity GO:0015199
Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid.
3 A0A0E4G213 (/IDA) A0A0R4IKJ8 (/IDA) A0A2R8QJH3 (/IDA)
Carnitine transmembrane transporter activity GO:0015226
Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
3 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO) Q9Z306 (/ISO)
Quaternary ammonium group transmembrane transporter activity GO:0015651
Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
3 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO) Q9Z306 (/ISO)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
3 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO) Q9Z306 (/ISO)
Quaternary ammonium group transmembrane transporter activity GO:0015651
Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
2 O70594 (/IMP) Q9R141 (/IMP)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
2 O76082 (/IPI) Q9H015 (/IPI)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
1 Q9H015 (/TAS)
Secondary active organic cation transmembrane transporter activity GO:0008513
Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.
1 Q9H015 (/TAS)
Organic cation transmembrane transporter activity GO:0015101
Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.
1 Q9R141 (/IDA)
Organic cation transmembrane transporter activity GO:0015101
Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.
1 Q9Z306 (/ISO)
Carnitine transmembrane transporter activity GO:0015226
Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
1 O76082 (/EXP)
Cation:cation antiporter activity GO:0015491
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out).
1 Q9H015 (/IDA)
Cation:cation antiporter activity GO:0015491
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out).
1 Q9Z306 (/ISO)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
1 O76082 (/IC)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Carnitine transport GO:0015879
The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
9 A0A0R4IMT8 (/IDA) O70594 (/IDA) O76082 (/IDA) Q9H015 (/IDA) Q9WTN6 (/IDA) Q9WTN6 (/IDA) Q9Z0E8 (/IDA) Q9Z0E8 (/IDA) Q9Z306 (/IDA)
Quaternary ammonium group transport GO:0015697
The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
7 O70594 (/IDA) O76082 (/IDA) Q9H015 (/IDA) Q9R141 (/IDA) Q9Z0E8 (/IDA) Q9Z0E8 (/IDA) Q9Z306 (/IDA)
Carnitine transport GO:0015879
The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
4 O70594 (/IMP) O76082 (/IMP) Q9Z0E8 (/IMP) Q9Z0E8 (/IMP)
Quaternary ammonium group transport GO:0015697
The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
3 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO) Q9Z306 (/ISO)
Amino-acid betaine transport GO:0015838
The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 A0A0E4G213 (/IDA) A0A0R4IKJ8 (/IDA) A0A2R8QJH3 (/IDA)
Carnitine transport GO:0015879
The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
3 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO) Q9Z306 (/ISO)
Selenium compound metabolic process GO:0001887
The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.
2 F1QKX0 (/IDA) Q6P695 (/IDA)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
2 Q9Z0E8 (/IMP) Q9Z0E8 (/IMP)
Adult heart development GO:0007512
The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.
2 Q9Z0E8 (/IMP) Q9Z0E8 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
2 Q9Z0E8 (/IMP) Q9Z0E8 (/IMP)
Carnitine metabolic process GO:0009437
The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
2 Q9Z0E8 (/IMP) Q9Z0E8 (/IMP)
Quaternary ammonium group transport GO:0015697
The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
2 O70594 (/IMP) Q9R141 (/IMP)
Inorganic anion transport GO:0015698
The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.
2 F1QKX0 (/IMP) Q6P695 (/IMP)
Reproductive structure development GO:0048608
The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.
2 Q9Z0E8 (/IMP) Q9Z0E8 (/IMP)
Detoxification of mercury ion GO:0050787
Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg
2 F1QKX0 (/IDA) Q6P695 (/IDA)
Response to methylmercury GO:0051597
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus.
2 F1QKX0 (/IMP) Q6P695 (/IMP)
Quorum sensing involved in interaction with host GO:0052106
The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO)
Positive regulation of intestinal epithelial structure maintenance GO:0060731
Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.
2 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO)
Sodium-dependent organic cation transport GO:0070715
The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO)
Triglyceride metabolic process GO:0006641
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
1 Q9Z306 (/IGI)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
1 A0A0R4IMT8 (/IMP)
Body fluid secretion GO:0007589
The controlled release of a fluid by a cell or tissue in an animal.
1 Q9H015 (/TAS)
Carnitine metabolic process GO:0009437
The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
1 Q9Z306 (/IGI)
Organic cation transport GO:0015695
The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.
1 Q9H015 (/TAS)
Drug transport GO:0015893
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O76082 (/IC)
Quorum sensing involved in interaction with host GO:0052106
The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 O76082 (/IMP)
Positive regulation of intestinal epithelial structure maintenance GO:0060731
Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.
1 O76082 (/IMP)
Sodium-dependent organic cation transport GO:0070715
The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O76082 (/IDA)
Carnitine transmembrane transport GO:1902603
The directed movement of carnitine across a membrane.
1 O76082 (/TAS)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO) Q9Z306 (/ISO)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
3 O76082 (/IDA) Q9Z0E8 (/IDA) Q9Z0E8 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9H015 (/IDA) Q9Z306 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 Q9WTN6 (/IDA) Q9WTN6 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O76082 (/IC) Q9H015 (/IC)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O76082 (/TAS) Q9H015 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9Z0E8 (/IC) Q9Z0E8 (/IC)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 O76082 (/IDA) Q9H015 (/IDA)
Intrinsic component of peroxisomal membrane GO:0031231
The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
2 Q9WTN6 (/IDA) Q9WTN6 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
2 Q9Z0E8 (/ISO) Q9Z0E8 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9Z306 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9Z306 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9H015 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O70594 (/NAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 O70594 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 O76082 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O76082 (/HDA)
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