The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 55: Facilitated trehalose transporter Tret1-2 homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Trehalose transmembrane transporter activity GO:0015574
Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens.
13 B0WC46 (/ISS) B3MG58 (/ISS) B3NSE1 (/ISS) B4GAP7 (/ISS) B4HNS0 (/ISS) B4J913 (/ISS) B4KR05 (/ISS) B4LPX5 (/ISS) B4MYA4 (/ISS) B4P624 (/ISS)
(3 more)
Fructose transmembrane transporter activity GO:0005353
Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
5 P58354 (/ISS) P58354 (/ISS) Q9JJZ1 (/ISS) Q9NY64 (/ISS) Q9NY64 (/ISS)
Glucose transmembrane transporter activity GO:0005355
Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
5 P58354 (/ISS) P58354 (/ISS) Q9JJZ1 (/ISS) Q9NY64 (/ISS) Q9NY64 (/ISS)
Trehalose transmembrane transporter activity GO:0015574
Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens.
5 A1Z8N1 (/IDA) A5LGM7 (/IDA) A9ZSY2 (/IDA) A9ZSY3 (/IDA) Q7PIR5 (/IDA)
Dehydroascorbic acid transmembrane transporter activity GO:0033300
Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other.
4 P58354 (/ISS) P58354 (/ISS) Q9NY64 (/ISS) Q9NY64 (/ISS)
Glucose transmembrane transporter activity GO:0005355
Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
2 Q9NY64 (/TAS) Q9NY64 (/TAS)
Dehydroascorbic acid transmembrane transporter activity GO:0033300
Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other.
2 Q9JIF3 (/IDA) Q9JJZ1 (/IDA)
Fructose transmembrane transporter activity GO:0005353
Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
1 Q9JIF3 (/IDA)
Galactose transmembrane transporter activity GO:0005354
Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
1 Q9JIF3 (/ISO)
Glucose transmembrane transporter activity GO:0005355
Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
1 Q9JIF3 (/IDA)
Glucose binding GO:0005536
Interacting selectively and non-covalently with the D- or L-enantiomer of glucose.
1 Q9JIF3 (/IDA)
Fructose uniporter activity GO:0015284
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in).
1 Q9JIF3 (/ISO)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Trehalose transport GO:0015771
The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.
13 B0WC46 (/ISS) B3MG58 (/ISS) B3NSE1 (/ISS) B4GAP7 (/ISS) B4HNS0 (/ISS) B4J913 (/ISS) B4KR05 (/ISS) B4LPX5 (/ISS) B4MYA4 (/ISS) B4P624 (/ISS)
(3 more)
Fructose transmembrane transport GO:0015755
The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
5 P58354 (/ISS) P58354 (/ISS) Q9JJZ1 (/ISS) Q9NY64 (/ISS) Q9NY64 (/ISS)
Trehalose transport GO:0015771
The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.
5 A1Z8N1 (/IDA) A5LGM7 (/IDA) A9ZSY2 (/IDA) A9ZSY3 (/IDA) Q7PIR5 (/IDA)
Glucose transmembrane transport GO:1904659
The process in which glucose is transported across a membrane.
5 P58354 (/ISS) P58354 (/ISS) Q9JJZ1 (/ISS) Q9NY64 (/ISS) Q9NY64 (/ISS)
Dehydroascorbic acid transport GO:0070837
The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C.
4 P58354 (/ISS) P58354 (/ISS) Q9NY64 (/ISS) Q9NY64 (/ISS)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
2 Q9NY64 (/TAS) Q9NY64 (/TAS)
Hexose transmembrane transport GO:0008645
The process in which hexose is transported across a membrane. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.
2 Q9NY64 (/TAS) Q9NY64 (/TAS)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
2 Q9NY64 (/TAS) Q9NY64 (/TAS)
Dehydroascorbic acid transport GO:0070837
The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C.
2 Q9JIF3 (/IDA) Q9JJZ1 (/IDA)
Glucose transmembrane transport GO:1904659
The process in which glucose is transported across a membrane.
2 Q9NY64 (/TAS) Q9NY64 (/TAS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q9JIF3 (/IDA)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 Q9JIF3 (/TAS)
Male meiosis I GO:0007141
A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.
1 Q9JJZ1 (/IEP)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
1 Q9JIF3 (/IDA)
Fructose transmembrane transport GO:0015755
The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
1 Q9JIF3 (/IDA)
Fructose transmembrane transport GO:0015755
The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
1 Q9JIF3 (/ISO)
Galactose transmembrane transport GO:0015757
The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
1 Q9JIF3 (/ISO)
Glucose transmembrane transport GO:1904659
The process in which glucose is transported across a membrane.
1 Q9JIF3 (/IDA)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
16 B0WC46 (/ISS) B3MG58 (/ISS) B3NSE1 (/ISS) B4GAP7 (/ISS) B4HNS0 (/ISS) B4HNS1 (/ISS) B4J913 (/ISS) B4KR05 (/ISS) B4LPX5 (/ISS) B4MYA4 (/ISS)
(6 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 A1Z8N1 (/IDA) A5LGM7 (/IDA) A9ZSY2 (/IDA) A9ZSY3 (/IDA) Q7PIR5 (/IDA) Q8MKK4 (/IDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
2 Q9NY64 (/HDA) Q9NY64 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8IQH6 (/HDA) Q9VU17 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9NY64 (/TAS) Q9NY64 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9NY64 (/TAS) Q9NY64 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 A1Z8N1 (/IDA) Q8MKK4 (/IDA)
Clathrin-coated vesicle membrane GO:0030665
The lipid bilayer surrounding a clathrin-coated vesicle.
2 Q9NY64 (/TAS) Q9NY64 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9JIF3 (/IDA)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 Q9JJZ1 (/IDA)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 Q9JIF3 (/ISO)
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