The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Hexose transporter Hxt3p

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fructose transmembrane transporter activity GO:0005353
Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
28 O74849 (/IGI) O74969 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P39924 (/IGI)
(18 more)
Glucose transmembrane transporter activity GO:0005355
Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
28 O74849 (/IGI) O74969 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P39924 (/IGI)
(18 more)
Mannose transmembrane transporter activity GO:0015578
Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
25 P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P39924 (/IGI) P40885 (/IGI) P40886 (/IGI)
(15 more)
Glucose transmembrane transporter activity GO:0005355
Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
21 P13181 (/IDA) P23585 (/IDA) P23585 (/IDA) P32466 (/IDA) P32466 (/IDA) P32466 (/IDA) P32466 (/IDA) P32466 (/IDA) P32467 (/IDA) P38695 (/IDA)
(11 more)
Mannose transmembrane transporter activity GO:0015578
Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
13 P23585 (/TAS) P23585 (/TAS) P32465 (/TAS) P32465 (/TAS) P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32467 (/TAS)
(3 more)
Fructose transmembrane transporter activity GO:0005353
Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
11 P23585 (/TAS) P23585 (/TAS) P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32467 (/TAS) P39003 (/TAS) P39004 (/TAS)
(1 more)
Glucose transmembrane transporter activity GO:0005355
Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
11 P38695 (/IMP) P38695 (/IMP) P38695 (/IMP) P38695 (/IMP) P38695 (/IMP) P38695 (/IMP) P38695 (/IMP) P39004 (/IMP) P39004 (/IMP) Q5B0S0 (/IMP)
(1 more)
Galactose transmembrane transporter activity GO:0005354
Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
8 P40885 (/IGI) P43581 (/IGI) P43581 (/IGI) P43581 (/IGI) P43581 (/IGI) P43581 (/IGI) P43581 (/IGI) P54862 (/IGI)
Pentose transmembrane transporter activity GO:0015146
Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms,
7 P23585 (/IMP) P23585 (/IMP) P32465 (/IMP) P32465 (/IMP) P32467 (/IMP) P39004 (/IMP) P39004 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P43581 (/IPI) P43581 (/IPI) P43581 (/IPI) P43581 (/IPI) P43581 (/IPI) P43581 (/IPI)
Fructose transmembrane transporter activity GO:0005353
Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
2 P32465 (/IMP) P32465 (/IMP)
Galactose transmembrane transporter activity GO:0005354
Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
2 P32465 (/TAS) P32465 (/TAS)
Glucose transmembrane transporter activity GO:0005355
Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
2 P32465 (/TAS) P32465 (/TAS)
Mannose transmembrane transporter activity GO:0015578
Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
2 Q5B0S0 (/IDA) Q5B0S0 (/IDA)
Galactose transmembrane transporter activity GO:0005354
Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
1 P13181 (/IMP)
High-affinity glucose:proton symporter activity GO:0005358
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
1 Q9P3U6 (/IMP)
Gluconate transmembrane transporter activity GO:0015128
Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose.
1 Q92339 (/IMP)
Hexose transmembrane transporter activity GO:0015149
Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other.
1 Q8TFG1 (/NAS)
High-affinity glucose transmembrane transporter activity GO:0140108
Enables the transfer of glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
1 P78831 (/IMP)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hexose transmembrane transport GO:0008645
The process in which hexose is transported across a membrane. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.
25 P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P38695 (/IGI) P39924 (/IGI) P40885 (/IGI) P40886 (/IGI)
(15 more)
Glucose transmembrane transport GO:1904659
The process in which glucose is transported across a membrane.
14 P23585 (/IMP) P23585 (/IMP) P32465 (/IMP) P32465 (/IMP) P38695 (/IMP) P38695 (/IMP) P38695 (/IMP) P38695 (/IMP) P38695 (/IMP) P38695 (/IMP)
(4 more)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
10 P39924 (/IGI) P43581 (/IGI) P43581 (/IGI) P43581 (/IGI) P43581 (/IGI) P43581 (/IGI) P43581 (/IGI) P54854 (/IGI) P54854 (/IGI) P54854 (/IGI)
Hexose transmembrane transport GO:0008645
The process in which hexose is transported across a membrane. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.
9 P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32467 (/TAS) P39003 (/TAS) P39004 (/TAS) P39004 (/TAS)
Sorbitol transport GO:0015795
The directed movement of sorbitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose.
8 P39924 (/IGI) P47185 (/IGI) P53631 (/IGI) P53631 (/IGI) P53631 (/IGI) P54854 (/IGI) P54854 (/IGI) P54854 (/IGI)
Mannitol transport GO:0015797
The directed movement of mannitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group.
8 P39924 (/IGI) P47185 (/IGI) P53631 (/IGI) P53631 (/IGI) P53631 (/IGI) P54854 (/IGI) P54854 (/IGI) P54854 (/IGI)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
8 P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P32466 (/TAS) P39003 (/TAS) P39004 (/TAS) P39004 (/TAS)
Glucose transmembrane transport GO:1904659
The process in which glucose is transported across a membrane.
7 P32466 (/IDA) P32466 (/IDA) P32466 (/IDA) P32466 (/IDA) P32466 (/IDA) P39004 (/IDA) P39004 (/IDA)
Xylitol transport GO:1902341
The directed movement of a xylitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xylitol is a polyalcohol (pentane-1,2,3,4,5-pentol), produced by hydrogenation of xylose.
4 P54854 (/IGI) P54854 (/IGI) P54854 (/IGI) P54862 (/IGI)
Glucose import across plasma membrane GO:0098708
The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol.
3 O74849 (/IGI) O74969 (/IGI) P78831 (/IGI)
Fructose import across plasma membrane GO:1990539
The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol.
3 O74849 (/IGI) O74969 (/IGI) P78831 (/IGI)
Mannose transmembrane transport GO:0015761
The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
2 P32465 (/IMP) P32465 (/IMP)
Carbohydrate transmembrane transport GO:0034219
The process in which a carbohydrate is transported across a membrane.
2 Q5B0S0 (/IDA) Q5B0S0 (/IDA)
Glucose import across plasma membrane GO:0098708
The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol.
2 P78831 (/IMP) Q9P3U6 (/IMP)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
1 P13181 (/IMP)
Hexose transmembrane transport GO:0008645
The process in which hexose is transported across a membrane. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.
1 Q8TFG1 (/NAS)
Galactose transmembrane transport GO:0015757
The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
1 P13181 (/IMP)
Gluconate transmembrane transport GO:0035429
The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose.
1 Q92339 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 A0A1D8PG81 (/IMP)
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
1 P78831 (/IMP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
38 P13181 (/HDA) P23585 (/HDA) P23585 (/HDA) P32465 (/HDA) P32465 (/HDA) P32466 (/HDA) P32466 (/HDA) P32466 (/HDA) P32466 (/HDA) P32466 (/HDA)
(28 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
25 A0A1D8PG81 (/IDA) A0A1D8PG82 (/IDA) O59932 (/IDA) O74849 (/IDA) O74969 (/IDA) P13181 (/IDA) P23585 (/IDA) P23585 (/IDA) P32465 (/IDA) P32465 (/IDA)
(15 more)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
12 P23585 (/HDA) P23585 (/HDA) P40885 (/HDA) P43581 (/HDA) P43581 (/HDA) P43581 (/HDA) P43581 (/HDA) P43581 (/HDA) P43581 (/HDA) P53631 (/HDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 P38695 (/HDA) P38695 (/HDA) P38695 (/HDA) P38695 (/HDA) P38695 (/HDA) P38695 (/HDA) P38695 (/HDA) P39003 (/HDA) P39004 (/HDA) P39004 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
9 P39003 (/HDA) P39004 (/HDA) P39004 (/HDA) P43581 (/HDA) P43581 (/HDA) P43581 (/HDA) P43581 (/HDA) P43581 (/HDA) P43581 (/HDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 O74849 (/IC) O74969 (/IC) P78831 (/IC) Q9P3U6 (/IC)
Plasma membrane of cell tip GO:0031520
The portion of the plasma membrane surrounding the cell tip.
4 O59932 (/IDA) P78831 (/IDA) Q92339 (/IDA) Q9P3U6 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 O59932 (/TAS) Q92339 (/TAS) Q9P3U7 (/TAS)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
2 Q5B0S0 (/IDA) Q5B0S0 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 P39924 (/HDA) Q8TFG1 (/HDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
1 O74849 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8TFG1 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 O74969 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P39003 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8TFG1 (/NAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q5AD47 (/IDA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 O74849 (/HDA)
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
1 O74849 (/HDA)
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