The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"MFS general substrate transporter like domains
".
FunFam 30: monocarboxylate transporter 1 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Lactate transmembrane transporter activity GO:0015129
Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
|
5 | O70451 (/ISS) O70451 (/ISS) P53988 (/ISS) P53988 (/ISS) Q63344 (/ISS) |
Pyruvate transmembrane transporter activity GO:0050833
Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other.
|
5 | O70451 (/ISS) O70451 (/ISS) P53988 (/ISS) P53988 (/ISS) Q63344 (/ISS) |
Pyruvate secondary active transmembrane transporter activity GO:0005477
Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
|
3 | O60669 (/TAS) O60669 (/TAS) O60669 (/TAS) |
Monocarboxylic acid transmembrane transporter activity GO:0008028
Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group.
|
3 | P53985 (/TAS) P53985 (/TAS) Q63344 (/TAS) |
Lactate transmembrane transporter activity GO:0015129
Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
|
3 | O60669 (/IDA) O60669 (/IDA) O60669 (/IDA) |
Pyruvate transmembrane transporter activity GO:0050833
Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other.
|
3 | O60669 (/IDA) O60669 (/IDA) O60669 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P53987 (/IPI) Q63344 (/IPI) |
Lactate transmembrane transporter activity GO:0015129
Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
|
2 | O70451 (/ISO) O70451 (/ISO) |
Mevalonate transmembrane transporter activity GO:0015130
Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds.
|
2 | P53985 (/TAS) P53985 (/TAS) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P53986 (/ISO) P53986 (/ISO) |
Pyruvate transmembrane transporter activity GO:0050833
Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other.
|
2 | O70451 (/ISO) O70451 (/ISO) |
Organic cyclic compound binding GO:0097159
Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
|
2 | P53986 (/ISO) P53986 (/ISO) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P53987 (/IDA) |
Organic cyclic compound binding GO:0097159
Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
|
1 | P53987 (/IMP) |
Organic cyclic compound binding GO:0097159
Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
|
1 | P53987 (/IPI) |
There are 25 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane lactate transport GO:0035879
The directed movement of lactate across a plasma membrane.
|
7 | P53985 (/ISS) P53985 (/ISS) P53986 (/ISS) P53986 (/ISS) Q03064 (/ISS) Q03064 (/ISS) Q3MHW6 (/ISS) |
Lactate transmembrane transport GO:0035873
The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
|
5 | O70451 (/ISS) O70451 (/ISS) P53988 (/ISS) P53988 (/ISS) Q63344 (/ISS) |
Pyruvate transmembrane transport GO:1901475
The directed movement of pyruvate across a membrane.
|
5 | O70451 (/ISS) O70451 (/ISS) P53988 (/ISS) P53988 (/ISS) Q63344 (/ISS) |
Lactate transmembrane transport GO:0035873
The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
|
4 | O60669 (/IMP) O60669 (/IMP) O60669 (/IMP) P53987 (/IMP) |
Lactate transmembrane transport GO:0035873
The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
|
4 | O70451 (/ISO) O70451 (/ISO) P53986 (/ISO) P53986 (/ISO) |
Plasma membrane lactate transport GO:0035879
The directed movement of lactate across a plasma membrane.
|
4 | O70451 (/ISO) O70451 (/ISO) P53986 (/ISO) P53986 (/ISO) |
Pyruvate transmembrane transport GO:1901475
The directed movement of pyruvate across a membrane.
|
3 | O60669 (/IDA) O60669 (/IDA) O60669 (/IDA) |
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
|
2 | P53985 (/TAS) P53985 (/TAS) |
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
|
2 | P53986 (/IMP) P53986 (/IMP) |
Centrosome cycle GO:0007098
The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
|
2 | P53985 (/IMP) P53985 (/IMP) |
Centrosome cycle GO:0007098
The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
|
2 | P53986 (/ISO) P53986 (/ISO) |
Monocarboxylic acid transport GO:0015718
The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P53985 (/TAS) P53985 (/TAS) |
Mevalonate transport GO:0015728
The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P53985 (/TAS) P53985 (/TAS) |
Response to food GO:0032094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.
|
2 | P53986 (/IMP) P53986 (/IMP) |
Plasma membrane lactate transport GO:0035879
The directed movement of lactate across a plasma membrane.
|
2 | P53987 (/IDA) Q63344 (/IDA) |
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
2 | P53986 (/IMP) P53986 (/IMP) |
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
|
2 | P53986 (/IMP) P53986 (/IMP) |
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
2 | P53985 (/TAS) P53985 (/TAS) |
Behavioral response to nutrient GO:0051780
Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus.
|
2 | P53986 (/IMP) P53986 (/IMP) |
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
2 | P53986 (/ISO) P53986 (/ISO) |
Pyruvate transmembrane transport GO:1901475
The directed movement of pyruvate across a membrane.
|
2 | O70451 (/ISO) O70451 (/ISO) |
Lactate transmembrane transport GO:0035873
The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
|
1 | P53987 (/IDA) |
Plasma membrane lactate transport GO:0035879
The directed movement of lactate across a plasma membrane.
|
1 | P53987 (/IMP) |
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
1 | P53987 (/IEP) |
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
1 | P53987 (/IMP) |
There are 32 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
12 |
O70451 (/ISS)
O70451 (/ISS)
P53985 (/ISS)
P53985 (/ISS)
P53986 (/ISS)
P53986 (/ISS)
P53988 (/ISS)
P53988 (/ISS)
Q03064 (/ISS)
Q03064 (/ISS)
(2 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | A0A024R0H1 (/IDA) A0A024R0H1 (/IDA) P53985 (/IDA) P53985 (/IDA) P53987 (/IDA) Q5T8R5 (/IDA) Q63344 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
6 | O60669 (/IDA) O60669 (/IDA) O60669 (/IDA) P53985 (/IDA) P53985 (/IDA) P53987 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P53986 (/ISS) P53986 (/ISS) Q03064 (/ISS) Q03064 (/ISS) Q3MHW6 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | O60669 (/TAS) O60669 (/TAS) O60669 (/TAS) P53985 (/TAS) P53985 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | O70451 (/ISO) O70451 (/ISO) P53986 (/ISO) P53986 (/ISO) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | O70451 (/ISO) O70451 (/ISO) P53986 (/ISO) P53986 (/ISO) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
4 | A0A024R0H1 (/IDA) A0A024R0H1 (/IDA) P53985 (/IDA) P53985 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
4 | A0A024R0H1 (/IDA) A0A024R0H1 (/IDA) P53985 (/IDA) P53985 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O70451 (/ISO) O70451 (/ISO) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P53986 (/HDA) P53986 (/HDA) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
2 | P53985 (/IDA) P53985 (/IDA) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
2 | P53986 (/ISO) P53986 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P53985 (/HDA) P53985 (/HDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P53985 (/TAS) P53985 (/TAS) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P53985 (/TAS) P53985 (/TAS) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
2 | P53986 (/ISO) P53986 (/ISO) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | P53986 (/ISO) P53986 (/ISO) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
2 | P53986 (/EXP) P53986 (/EXP) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
2 | P53986 (/IDA) P53986 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | P53985 (/HDA) P53985 (/HDA) |
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
|
2 | O70451 (/ISO) O70451 (/ISO) |
Hippocampal mossy fiber to CA3 synapse GO:0098686
One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
|
2 | O70451 (/ISO) O70451 (/ISO) |
Parallel fiber to Purkinje cell synapse GO:0098688
An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.
|
2 | O70451 (/ISO) O70451 (/ISO) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
2 | O70451 (/ISO) O70451 (/ISO) |
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | O70451 (/ISO) O70451 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q63344 (/IDA) |
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
|
1 | Q63344 (/IDA) |
Hippocampal mossy fiber to CA3 synapse GO:0098686
One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
|
1 | Q63344 (/IDA) |
Parallel fiber to Purkinje cell synapse GO:0098688
An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.
|
1 | Q63344 (/IDA) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | Q63344 (/IDA) |
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q63344 (/IDA) |