The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 264: vesicular glutamate transporter 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-glutamate transmembrane transporter activity GO:0005313
Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
2 Q86P76 (/IC) Q9VQC0 (/IC)
L-glutamate transmembrane transporter activity GO:0005313
Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
2 Q86P76 (/ISA) Q9VQC0 (/ISA)
Neurotransmitter transmembrane transporter activity GO:0005326
Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
2 Q86P76 (/IMP) Q9VQC0 (/IMP)
Glutamate:sodium symporter activity GO:0015501
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in).
1 P34644 (/ISS)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Synaptic transmission, glutamatergic GO:0035249
The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
3 P34644 (/IMP) Q86P76 (/IMP) Q9VQC0 (/IMP)
L-glutamate transmembrane transport GO:0015813
The directed movement of L-glutamate across a membrane.
2 Q86P76 (/ISA) Q9VQC0 (/ISA)
Regulation of membrane potential in photoreceptor cell GO:0016057
Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.
2 Q86P76 (/IGI) Q9VQC0 (/IGI)
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
1 P34644 (/IMP)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
1 P34644 (/IMP)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P34644 (/IGI)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P34644 (/IMP)
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
1 P34644 (/IMP)
L-glutamate transmembrane transport GO:0015813
The directed movement of L-glutamate across a membrane.
1 P34644 (/ISS)
Regulation of pharyngeal pumping GO:0043051
Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
1 P34644 (/IGI)
Regulation of pharyngeal pumping GO:0043051
Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
1 P34644 (/IMP)
Negative regulation of turning behavior involved in mating GO:0061096
Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail.
1 P34644 (/IMP)
Positive regulation of neuromuscular synaptic transmission GO:1900075
Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission.
1 Q9VQC0 (/IMP)
Positive regulation of backward locomotion GO:1905852
Any process that activates or increases the frequency, rate or extent of backward locomotion.
1 P34644 (/IGI)
Positive regulation of backward locomotion GO:1905852
Any process that activates or increases the frequency, rate or extent of backward locomotion.
1 P34644 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
2 Q86P76 (/IDA) Q9VQC0 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q86P76 (/ISM) Q9VQC0 (/ISM)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q86P76 (/ISS) Q9VQC0 (/ISS)
Integral component of synaptic vesicle membrane GO:0030285
The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q86P76 (/IC) Q9VQC0 (/IC)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
2 Q86P76 (/IDA) Q9VQC0 (/IDA)
Integral component of synaptic vesicle membrane GO:0030285
The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P34644 (/ISS)
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