The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 197: Siderophore iron transporter 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Siderophore transmembrane transporter activity GO:0015343
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in).
3 P38724 (/IMP) P38731 (/IMP) P38731 (/IMP)
Ferrichrome transmembrane transporter activity GO:0042929
Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.
3 Q5A2T6 (/IGI) Q5A2T6 (/IGI) Q5A2T6 (/IGI)
Ferrichrome transmembrane transporter activity GO:0042929
Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.
3 Q5A2T6 (/IMP) Q5A2T6 (/IMP) Q5A2T6 (/IMP)
Solute:proton antiporter activity GO:0015299
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
2 P25596 (/IMP) P25596 (/IMP)
Siderophore uptake transmembrane transporter activity GO:0015344
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in).
2 P39980 (/IMP) P39980 (/IMP)
Solute:proton antiporter activity GO:0015299
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
1 P36173 (/ISA)
Siderophore transmembrane transporter activity GO:0015343
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in).
1 P38724 (/IDA)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Siderophore transport GO:0015891
The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
5 P38724 (/IMP) P38731 (/IMP) P38731 (/IMP) P39980 (/IMP) P39980 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
3 P38724 (/IMP) P39980 (/IMP) P39980 (/IMP)
Siderophore transport GO:0015891
The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q5A2T6 (/ISS) Q5A2T6 (/ISS) Q5A2T6 (/ISS)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
3 Q5A2T6 (/IMP) Q5A2T6 (/IMP) Q5A2T6 (/IMP)
Ferrichrome import into cell GO:0042928
A process in which ferrichrome is transported into the cell by specific cell surface receptors. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.
3 Q5A2T6 (/IEP) Q5A2T6 (/IEP) Q5A2T6 (/IEP)
Ferrichrome import into cell GO:0042928
A process in which ferrichrome is transported into the cell by specific cell surface receptors. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.
3 Q5A2T6 (/IGI) Q5A2T6 (/IGI) Q5A2T6 (/IGI)
Ferrichrome import into cell GO:0042928
A process in which ferrichrome is transported into the cell by specific cell surface receptors. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.
3 Q5A2T6 (/IMP) Q5A2T6 (/IMP) Q5A2T6 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
2 P39980 (/IDA) P39980 (/IDA)
Glutathione transmembrane transport GO:0034775
A process in which glutathione is transported across a membrane.
2 P25596 (/IMP) P25596 (/IMP)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
2 P39980 (/IMP) P39980 (/IMP)
Siderophore metabolic process GO:0009237
The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
1 P38724 (/IMP)
Siderophore transport GO:0015891
The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P38724 (/IDA)
Siderophore-dependent iron import into cell GO:0033214
A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors.
1 O74395 (/TAS)
Glutathione transmembrane transport GO:0034775
A process in which glutathione is transported across a membrane.
1 P36173 (/ISA)
Siderophore transmembrane transport GO:0044718
The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore.
1 O74395 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 P25596 (/IDA) P25596 (/IDA) P36173 (/IDA) P38731 (/IDA) P38731 (/IDA) Q5A2T6 (/IDA) Q5A2T6 (/IDA) Q5A2T6 (/IDA) Q6FV79 (/IDA) Q6FV79 (/IDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
5 P38724 (/HDA) P38731 (/HDA) P38731 (/HDA) P39980 (/HDA) P39980 (/HDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
5 P25596 (/HDA) P25596 (/HDA) P36173 (/HDA) P38731 (/HDA) P38731 (/HDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
4 P38731 (/IDA) P38731 (/IDA) P39980 (/IDA) P39980 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
4 P38731 (/IDA) P38731 (/IDA) P39980 (/IDA) P39980 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q5A2T6 (/IDA) Q5A2T6 (/IDA) Q5A2T6 (/IDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
3 P25596 (/IDA) P25596 (/IDA) P36173 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 Q5A2T6 (/IDA) Q5A2T6 (/IDA) Q5A2T6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P38731 (/HDA) P38731 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P38731 (/HDA) P38731 (/HDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 O74395 (/HDA)
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