The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"MFS general substrate transporter like domains
".
FunFam 1545: Folate-biopterin transporter
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Folic acid transmembrane transporter activity GO:0008517
Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
2 | Q55721 (/IDA) Q55721 (/IDA) |
|
5-formyltetrahydrofolate transmembrane transporter activity GO:0015231
Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other.
|
2 | Q55721 (/IDA) Q55721 (/IDA) |
|
5-formyltetrahydrofolate transmembrane transporter activity GO:0015231
Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other.
|
2 | Q55721 (/IMP) Q55721 (/IMP) |
|
Methotrexate transmembrane transporter activity GO:0015350
Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
|
2 | Q55721 (/IDA) Q55721 (/IDA) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Folic acid transport GO:0015884
The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
|
2 | Q55721 (/IDA) Q55721 (/IDA) |
|
5-formyltetrahydrofolate transport GO:0015885
The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q55721 (/IDA) Q55721 (/IDA) |
|
5-formyltetrahydrofolate transport GO:0015885
The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q55721 (/IMP) Q55721 (/IMP) |
|
Methotrexate transport GO:0051958
The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
|
2 | Q55721 (/IDA) Q55721 (/IDA) |
There are 0 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
