The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 139: Solute carrier family 40 protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Iron ion transmembrane transporter activity GO:0005381
Enables the transfer of iron (Fe) ions from one side of a membrane to the other.
4 Q9I9R3 (/IMP) Q9NP59 (/IMP) Q9NP59 (/IMP) Q9NP59 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q9JHI9 (/IPI) Q9NP59 (/IPI) Q9NP59 (/IPI) Q9NP59 (/IPI)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
4 Q9JHI9 (/IPI) Q9NP59 (/IPI) Q9NP59 (/IPI) Q9NP59 (/IPI)
Iron ion transmembrane transporter activity GO:0005381
Enables the transfer of iron (Fe) ions from one side of a membrane to the other.
3 Q9NP59 (/ISS) Q9NP59 (/ISS) Q9NP59 (/ISS)
Ferrous iron transmembrane transporter activity GO:0015093
Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.
3 Q9NP59 (/ISS) Q9NP59 (/ISS) Q9NP59 (/ISS)
Iron ion transmembrane transporter activity GO:0005381
Enables the transfer of iron (Fe) ions from one side of a membrane to the other.
2 Q9I9R3 (/IDA) Q9JHI9 (/IDA)
Iron ion transmembrane transporter activity GO:0005381
Enables the transfer of iron (Fe) ions from one side of a membrane to the other.
1 Q9JHI9 (/ISO)
Iron ion transmembrane transporter activity GO:0005381
Enables the transfer of iron (Fe) ions from one side of a membrane to the other.
1 Q923U9 (/NAS)
Ferrous iron transmembrane transporter activity GO:0015093
Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.
1 Q9JHI9 (/IDA)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
1 Q9JHI9 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9JHI9 (/IPI)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
4 Q9I9R3 (/IMP) Q9NP59 (/IMP) Q9NP59 (/IMP) Q9NP59 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
3 Q9NP59 (/TAS) Q9NP59 (/TAS) Q9NP59 (/TAS)
Iron ion transmembrane transport GO:0034755
A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
3 Q9NP59 (/IMP) Q9NP59 (/IMP) Q9NP59 (/IMP)
Multicellular organismal iron ion homeostasis GO:0060586
Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism.
3 Q9NP59 (/ISS) Q9NP59 (/ISS) Q9NP59 (/ISS)
Iron ion export across plasma membrane GO:1903988
The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region.
3 Q9NP59 (/ISS) Q9NP59 (/ISS) Q9NP59 (/ISS)
Lymphocyte homeostasis GO:0002260
The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.
1 Q9JHI9 (/IMP)
Endothelium development GO:0003158
The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
1 Q9JHI9 (/IMP)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9JHI9 (/IDA)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9I9R3 (/IMP)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q923U9 (/NAS)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 Q9JHI9 (/ISO)
Response to iron ion GO:0010039
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
1 Q9I9R3 (/IDA)
Bone mineralization GO:0030282
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
1 Q9I9R3 (/IMP)
Regulation of transcription from RNA polymerase II promoter in response to iron GO:0034395
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus.
1 Q9JHI9 (/IDA)
Iron ion transmembrane transport GO:0034755
A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 Q9JHI9 (/IGI)
Iron ion transmembrane transport GO:0034755
A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 Q9JHI9 (/ISO)
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
1 Q9I9R3 (/IMP)
Hemoglobin biosynthetic process GO:0042541
The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
1 Q9I9R3 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q9JHI9 (/IMP)
Nucleate erythrocyte maturation GO:0043362
A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus.
1 Q9I9R3 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9JHI9 (/IGI)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
1 Q9I9R3 (/IDA)
Spleen development GO:0048536
The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.
1 Q9JHI9 (/IMP)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
1 Q9JHI9 (/IMP)
Spleen trabecula formation GO:0060345
The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod.
1 Q9JHI9 (/IMP)
Multicellular organismal iron ion homeostasis GO:0060586
Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism.
1 Q9JHI9 (/IMP)
Iron ion export across plasma membrane GO:1903988
The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region.
1 Q9JHI9 (/IDA)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q9JHI9 (/IDA) Q9NP59 (/IDA) Q9NP59 (/IDA) Q9NP59 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 Q9NP59 (/IDA) Q9NP59 (/IDA) Q9NP59 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q9NP59 (/TAS) Q9NP59 (/TAS) Q9NP59 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q9NP59 (/IDA) Q9NP59 (/IDA) Q9NP59 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q9NP59 (/TAS) Q9NP59 (/TAS) Q9NP59 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q9NP59 (/IC) Q9NP59 (/IC) Q9NP59 (/IC)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q9NP59 (/TAS) Q9NP59 (/TAS) Q9NP59 (/TAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
3 Q9NP59 (/IDA) Q9NP59 (/IDA) Q9NP59 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
3 Q9NP59 (/ISS) Q9NP59 (/ISS) Q9NP59 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9JHI9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9JHI9 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9JHI9 (/ISO)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 Q9JHI9 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9I9R3 (/ISS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q9JHI9 (/IGI)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q9JHI9 (/ISO)