The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MFS general substrate transporter like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: MFS multidrug transporter, putative

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Spermine transmembrane transporter activity GO:0000297
Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.
7 P53283 (/IMP) P53283 (/IMP) P53283 (/IMP) P53283 (/IMP) Q06451 (/IMP) Q07824 (/IMP) Q07824 (/IMP)
Spermine transmembrane transporter activity GO:0000297
Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.
7 O59698 (/ISO) O59699 (/ISO) O59700 (/ISO) O74829 (/ISO) O94528 (/ISO) Q10487 (/ISO) Q9Y7S4 (/ISO)
Spermidine transmembrane transporter activity GO:0015606
Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other.
5 O59698 (/ISO) O59699 (/ISO) O59700 (/ISO) O74829 (/ISO) Q9Y7S4 (/ISO)
Spermine transmembrane transporter activity GO:0000297
Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.
2 Q07824 (/IDA) Q07824 (/IDA)
Spermidine transmembrane transporter activity GO:0015606
Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other.
2 Q07824 (/IDA) Q07824 (/IDA)
Spermidine transmembrane transporter activity GO:0015606
Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other.
2 Q07824 (/IMP) Q07824 (/IMP)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
2 G1UB37 (/IMP) Q5ABU7 (/IMP)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
2 Q6FRT6 (/ISA) Q6FRT6 (/ISA)
Fluconazole transmembrane transporter activity GO:0015244
Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.
1 Q5ABU7 (/IDA)
Fluconazole transmembrane transporter activity GO:0015244
Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.
1 P38124 (/IMP)
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
1 Q9USN4 (/ISM)
Amide transmembrane transporter activity GO:0042887
Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other.
1 Q8NKG7 (/IMP)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
1 Q5ABU7 (/IDA)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
1 Q5ABU7 (/IGI)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Spermine transport GO:0000296
The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
9 P53283 (/IMP) P53283 (/IMP) P53283 (/IMP) P53283 (/IMP) Q06451 (/IMP) Q07824 (/IMP) Q07824 (/IMP) Q6FQ03 (/IMP) Q6FQ03 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
7 A0A1D8PQG0 (/IMP) Q59RG0 (/IMP) Q59RG0 (/IMP) Q5ABU7 (/IMP) Q6FTB1 (/IMP) Q6FTB1 (/IMP) Q6FV98 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
7 A0A1D8PEG8 (/IMP) A0A1D8PQG0 (/IMP) B9WJ41 (/IMP) B9WJ41 (/IMP) Q59RG0 (/IMP) Q59RG0 (/IMP) Q5ABU7 (/IMP)
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
6 G1UB37 (/IMP) P38124 (/IMP) Q5ABU7 (/IMP) Q6FRT5 (/IMP) Q6FRT6 (/IMP) Q6FRT6 (/IMP)
Spermine transmembrane transport GO:1903710
The process in which spermine is transported across a membrane.
5 O59698 (/IC) O59699 (/IC) O59700 (/IC) O74829 (/IC) Q9Y7S4 (/IC)
Spermidine transmembrane transport GO:1903711
The process in which spermidine is transported across a membrane.
5 O59698 (/IC) O59699 (/IC) O59700 (/IC) O74829 (/IC) Q9Y7S4 (/IC)
Hexose transmembrane transport GO:0008645
The process in which hexose is transported across a membrane. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.
3 A0A1D8PQG0 (/IMP) Q59RG0 (/IMP) Q59RG0 (/IMP)
Spermidine transport GO:0015848
The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 G1UB37 (/IMP) Q07824 (/IMP) Q07824 (/IMP)
Spermine transport GO:0000296
The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q07824 (/IDA) Q07824 (/IDA)
Putrescine transport GO:0015847
The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.
2 Q07824 (/IMP) Q07824 (/IMP)
Spermidine transport GO:0015848
The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q07824 (/IDA) Q07824 (/IDA)
Polyamine transmembrane transport GO:1902047
The process in which a polyamine macromolecule is transported across a membrane.
2 Q07824 (/IMP) Q07824 (/IMP)
Spermine transmembrane transport GO:1903710
The process in which spermine is transported across a membrane.
2 O94528 (/ISO) Q10487 (/ISO)
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
2 P38124 (/IGI) Q5ABU7 (/IGI)
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
2 Q6FRT6 (/ISA) Q6FRT6 (/ISA)
Peptide transport GO:0015833
The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 G1UB37 (/IMP)
Fluconazole transport GO:0015903
The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.
1 Q5ABU7 (/IDA)
Fluconazole transport GO:0015903
The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.
1 G1UB37 (/IGI)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q5ABU7 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q5ABU7 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q5ABU7 (/IDA)
Single-species biofilm formation GO:0044010
A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
1 Q6FV98 (/IMP)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
1 Q9USN4 (/ISM)
Xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
1 Q5ABU7 (/IDA)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
18 A0A1D8PJQ4 (/IDA) G1UB37 (/IDA) P38124 (/IDA) P53283 (/IDA) P53283 (/IDA) P53283 (/IDA) P53283 (/IDA) Q06451 (/IDA) Q07824 (/IDA) Q07824 (/IDA)
(8 more)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
8 P38124 (/HDA) P53283 (/HDA) P53283 (/HDA) P53283 (/HDA) P53283 (/HDA) Q06451 (/HDA) Q07824 (/HDA) Q07824 (/HDA)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
7 P53283 (/IMP) P53283 (/IMP) P53283 (/IMP) P53283 (/IMP) Q06451 (/IMP) Q07824 (/IMP) Q07824 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 O59698 (/ISO) O59699 (/ISO) O59700 (/ISO) O74829 (/ISO) O94528 (/ISO) Q10487 (/ISO) Q9Y7S4 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
5 O59699 (/HDA) O59700 (/HDA) Q10487 (/HDA) Q9USN4 (/HDA) Q9Y7S4 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 O94528 (/HDA) Q9Y7S4 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q07824 (/IMP) Q07824 (/IMP)
Cellular bud membrane GO:0033101
The portion of the plasma membrane surrounding a cellular bud.
2 Q07824 (/IDA) Q07824 (/IDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
1 O59700 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P38124 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P38124 (/HDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q5ABU7 (/IDA)
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