The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 69: Interleukin-6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 0 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 E3Q1F7 (/IDA) M5EF24 (/IDA) Q0GGL7 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 E3Q1F7 (/IDA) M5EF24 (/IDA) Q0GGL7 (/IDA)
Positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141
Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
3 E3Q1F7 (/IDA) M5EF24 (/IDA) Q0GGL7 (/IDA)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
3 E3Q1F7 (/IDA) M5EF24 (/IDA) Q0GGL7 (/IDA)
Activation of Janus kinase activity GO:0042976
The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
3 E3Q1F7 (/IMP) M5EF24 (/IMP) Q0GGL7 (/IMP)
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
3 E3Q1F7 (/IMP) M5EF24 (/IMP) Q0GGL7 (/IMP)
Macrophage proliferation GO:0061517
The expansion of a macrophage population by cell division.
3 E3Q1F7 (/IDA) M5EF24 (/IDA) Q0GGL7 (/IDA)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
3 E3Q1F7 (/IDA) M5EF24 (/IDA) Q0GGL7 (/IDA)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
3 E3Q1F7 (/IDA) M5EF24 (/IDA) Q0GGL7 (/IDA)
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
3 E3Q1F7 (/IDA) M5EF24 (/IDA) Q0GGL7 (/IDA)
Immune response involved in response to exogenous dsRNA GO:1902615
Any immune response that is involved in response to exogenous dsRNA.
3 E3Q1F7 (/IDA) M5EF24 (/IDA) Q0GGL7 (/IDA)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
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