The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 49: Interferon gamma

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Interferon-gamma receptor binding GO:0005133
Interacting selectively and non-covalently with the interferon-gamma receptor.
5 B6UQB6 (/IPI) B6UQB7 (/IPI) E3P8T4 (/IPI) E3P8T5 (/IPI) Q5QSL2 (/IPI)
Interferon-gamma receptor binding GO:0005133
Interacting selectively and non-covalently with the interferon-gamma receptor.
1 B3IXK1 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 B3IXK1 (/IDA)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
7 B6UQB6 (/IDA) B6UQB7 (/IDA) D2D0D7 (/IDA) E3P8T4 (/IDA) E3P8T5 (/IDA) Q5QRA1 (/IDA) Q5QSL2 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
7 B6UQB6 (/IMP) B6UQB7 (/IMP) D2D0D7 (/IMP) E3P8T4 (/IMP) E3P8T5 (/IMP) Q5QRA1 (/IMP) Q5QSL2 (/IMP)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
7 B6UQB6 (/IDA) B6UQB7 (/IDA) D2D0D7 (/IDA) E3P8T4 (/IDA) E3P8T5 (/IDA) Q5QRA1 (/IDA) Q5QSL2 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
5 B6UQB6 (/IDA) B6UQB7 (/IDA) E3P8T4 (/IDA) E3P8T5 (/IDA) Q5QSL2 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
5 B6UQB6 (/IMP) B6UQB7 (/IMP) E3P8T4 (/IMP) E3P8T5 (/IMP) Q5QSL2 (/IMP)
Negative regulation of cell killing GO:0031342
Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing.
5 B6UQB6 (/IDA) B6UQB7 (/IDA) E3P8T4 (/IDA) E3P8T5 (/IDA) Q5QSL2 (/IDA)
Negative regulation of viral transcription GO:0032897
Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription.
5 B6UQB6 (/IDA) B6UQB7 (/IDA) E3P8T4 (/IDA) E3P8T5 (/IDA) Q5QSL2 (/IDA)
Protein localization to organelle GO:0033365
A process in which a protein is transported to, or maintained in, a location within an organelle.
5 B6UQB6 (/IMP) B6UQB7 (/IMP) E3P8T4 (/IMP) E3P8T5 (/IMP) Q5QSL2 (/IMP)
Negative regulation of cytolysis GO:0045918
Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis.
5 B6UQB6 (/IDA) B6UQB7 (/IDA) E3P8T4 (/IDA) E3P8T5 (/IDA) Q5QSL2 (/IDA)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
5 B6UQB6 (/IMP) B6UQB7 (/IMP) E3P8T4 (/IMP) E3P8T5 (/IMP) Q5QSL2 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
5 B6UQB6 (/IDA) B6UQB7 (/IDA) E3P8T4 (/IDA) E3P8T5 (/IDA) Q5QSL2 (/IDA)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
5 B6UQB6 (/IMP) B6UQB7 (/IMP) E3P8T4 (/IMP) E3P8T5 (/IMP) Q5QSL2 (/IMP)
Negative regulation of viral translation GO:1904972
Any process that stops, prevents or reduces the frequency, rate or extent of viral translation.
5 B6UQB6 (/IDA) B6UQB7 (/IDA) E3P8T4 (/IDA) E3P8T5 (/IDA) Q5QSL2 (/IDA)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 D2D0D7 (/ISS) Q5QRA1 (/ISS) S0DGE5 (/ISS)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
3 D2D0D7 (/ISS) Q5QRA1 (/ISS) S0DGE5 (/ISS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 Q5RHV5 (/IDA) Q75S22 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 Q5RHV5 (/IDA) Q75S22 (/IDA)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
2 Q5RHV5 (/IMP) Q75S22 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 Q5RHV5 (/IDA) Q75S22 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 Q5RHV5 (/IGI) Q75S22 (/IGI)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 Q5RHV5 (/IMP) Q75S22 (/IMP)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 D2D0D7 (/IMP) Q5QRA1 (/IMP)
Positive regulation of respiratory burst GO:0060267
Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
2 B6UQB6 (/IDA) Q5QSL2 (/IDA)
Endothelial to hematopoietic transition GO:0098508
The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium.
2 Q5RHV5 (/IMP) Q75S22 (/IMP)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 D2D0D7 (/ISS)
Negative regulation of viral life cycle GO:1903901
Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle.
1 Q5QRA1 (/IDA)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
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