CATH Superfamily 1.20.1250.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 37: Prolactin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Superoxide-generating NADPH oxidase activator activity GO:0016176
Increases the activity of the enzyme superoxide-generating NADPH oxidase.
|
13 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P09584 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P69130 (/ISS)
P69130 (/ISS)
P69131 (/ISS)
(3 more) |
Prolactin receptor binding GO:0005148
Interacting selectively and non-covalently with the prolactin receptor.
|
10 | P09584 (/ISS) P34181 (/ISS) P48096 (/ISS) P48096 (/ISS) P69130 (/ISS) P69130 (/ISS) P69131 (/ISS) P69131 (/ISS) Q91170 (/ISS) Q91364 (/ISS) |
Prolactin receptor binding GO:0005148
Interacting selectively and non-covalently with the prolactin receptor.
|
2 | P21993 (/IMP) P21993 (/IMP) |
Superoxide-generating NADPH oxidase activator activity GO:0016176
Increases the activity of the enzyme superoxide-generating NADPH oxidase.
|
2 | P48096 (/IDA) P48096 (/IDA) |
There are 32 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of activation of Janus kinase activity GO:0010536
Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
|
13 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P09584 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P69130 (/ISS)
P69130 (/ISS)
P69131 (/ISS)
(3 more) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
13 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P09584 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P69130 (/ISS)
P69130 (/ISS)
P69131 (/ISS)
(3 more) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
13 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P09584 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P69130 (/ISS)
P69130 (/ISS)
P69131 (/ISS)
(3 more) |
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
13 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P09584 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P69130 (/ISS)
P69130 (/ISS)
P69131 (/ISS)
(3 more) |
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
13 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P09584 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P69130 (/ISS)
P69130 (/ISS)
P69131 (/ISS)
(3 more) |
Positive regulation of respiratory burst GO:0060267
Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
|
13 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P09584 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P69130 (/ISS)
P69130 (/ISS)
P69131 (/ISS)
(3 more) |
Positive regulation of reactive oxygen species biosynthetic process GO:1903428
Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process.
|
13 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P09584 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P69130 (/ISS)
P69130 (/ISS)
P69131 (/ISS)
(3 more) |
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
11 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P48096 (/ISS)
P48096 (/ISS)
P69131 (/ISS)
P69131 (/ISS)
(1 more) |
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
|
11 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P48096 (/ISS)
P48096 (/ISS)
P69131 (/ISS)
P69131 (/ISS)
(1 more) |
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
|
11 |
A0A060WYA2 (/ISS)
A0A060WYA2 (/ISS)
A0A060YRU3 (/ISS)
P21993 (/ISS)
P21993 (/ISS)
P34181 (/ISS)
P48096 (/ISS)
P48096 (/ISS)
P69131 (/ISS)
P69131 (/ISS)
(1 more) |
Positive regulation of leukocyte proliferation GO:0070665
Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.
|
10 | P09584 (/ISS) P34181 (/ISS) P48096 (/ISS) P48096 (/ISS) P69130 (/ISS) P69130 (/ISS) P69131 (/ISS) P69131 (/ISS) Q91170 (/ISS) Q91364 (/ISS) |
Regulation of immunoglobulin secretion GO:0051023
Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
|
9 | A0A060YRU3 (/ISS) P21993 (/ISS) P21993 (/ISS) P34181 (/ISS) P48096 (/ISS) P48096 (/ISS) P69131 (/ISS) P69131 (/ISS) Q91364 (/ISS) |
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
4 | P09584 (/IMP) P69130 (/IMP) P69130 (/IMP) Q91170 (/IMP) |
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
|
4 | P09584 (/IMP) P69130 (/IMP) P69130 (/IMP) Q91170 (/IMP) |
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
|
4 | P09584 (/IMP) P69130 (/IMP) P69130 (/IMP) Q91170 (/IMP) |
Regulation of immunoglobulin secretion GO:0051023
Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
|
4 | P09584 (/IMP) P69130 (/IMP) P69130 (/IMP) Q91170 (/IMP) |
Multicellular organismal response to stress GO:0033555
Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
3 | F1R0Y2 (/IEP) Q569P7 (/IEP) Q801K3 (/IEP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
3 | F1R0Y2 (/IMP) Q569P7 (/IMP) Q801K3 (/IMP) |
Ion homeostasis GO:0050801
Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
|
3 | F1R0Y2 (/IMP) Q569P7 (/IMP) Q801K3 (/IMP) |
Positive regulation of activation of Janus kinase activity GO:0010536
Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
|
2 | P48096 (/IDA) P48096 (/IDA) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | P48096 (/IDA) P48096 (/IDA) |
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
|
2 | P48096 (/IDA) P48096 (/IDA) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
2 | P48096 (/IDA) P48096 (/IDA) |
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
2 | P21993 (/IMP) P21993 (/IMP) |
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
2 | P48096 (/IDA) P48096 (/IDA) |
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
|
2 | P48096 (/IDA) P48096 (/IDA) |
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
2 | P48096 (/IDA) P48096 (/IDA) |
Positive regulation of respiratory burst GO:0060267
Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
|
2 | P48096 (/IDA) P48096 (/IDA) |
Positive regulation of leukocyte proliferation GO:0070665
Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.
|
2 | P21993 (/IDA) P21993 (/IDA) |
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
|
2 | P48096 (/IDA) P48096 (/IDA) |
Positive regulation of reactive oxygen species biosynthetic process GO:1903428
Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process.
|
2 | P48096 (/IDA) P48096 (/IDA) |
Positive regulation of lysozyme activity GO:1903592
Any process that activates or increases the frequency, rate or extent of lysozyme activity.
|
2 | P48096 (/IDA) P48096 (/IDA) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
4 | P21993 (/IDA) P21993 (/IDA) P48096 (/IDA) P48096 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P21993 (/IDA) P21993 (/IDA) |