The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 30: Type I interferon

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 0 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
16 A0FJI5 (/IDA) A8E0J6 (/IDA) A8KCK1 (/IDA) B3DGR6 (/IDA) B6UQB1 (/IDA) P0DMS7 (/IDA) Q5U778 (/IDA) Q6XQG7 (/IDA) Q70G08 (/IDA) Q70I18 (/IDA)
(6 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
10 A8E0J6 (/IDA) A8KCK1 (/IDA) B6UQB1 (/IDA) P0DMS7 (/IDA) Q1A3D7 (/IDA) Q5U778 (/IDA) Q6XQG6 (/IDA) Q6XQG7 (/IDA) Q70G08 (/IDA) Q70I18 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
8 A0FJI5 (/IDA) B3DGR6 (/IDA) Q75SZ2 (/IDA) Q76KA5 (/IDA) Q800G9 (/IDA) Q800H0 (/IDA) Q800H1 (/IDA) Q8AY12 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
8 A0FJI5 (/IDA) B3DGR6 (/IDA) Q75SZ2 (/IDA) Q76KA5 (/IDA) Q800G9 (/IDA) Q800H0 (/IDA) Q800H1 (/IDA) Q8AY12 (/IDA)
Response to exogenous dsRNA GO:0043330
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
8 A0FJI5 (/IDA) B3DGR6 (/IDA) Q75SZ2 (/IDA) Q76KA5 (/IDA) Q800G9 (/IDA) Q800H0 (/IDA) Q800H1 (/IDA) Q8AY12 (/IDA)
Response to arsenic-containing substance GO:0046685
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
8 A0FJI5 (/IDA) B3DGR6 (/IDA) Q75SZ2 (/IDA) Q76KA5 (/IDA) Q800G9 (/IDA) Q800H0 (/IDA) Q800H1 (/IDA) Q8AY12 (/IDA)
Regulation of defense response to virus by host GO:0050691
Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.
8 A0FJI5 (/IDA) B3DGR6 (/IDA) Q75SZ2 (/IDA) Q76KA5 (/IDA) Q800G9 (/IDA) Q800H0 (/IDA) Q800H1 (/IDA) Q8AY12 (/IDA)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
8 A0FJI5 (/IGI) B3DGR6 (/IGI) Q75SZ2 (/IGI) Q76KA5 (/IGI) Q800G9 (/IGI) Q800H0 (/IGI) Q800H1 (/IGI) Q8AY12 (/IGI)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
7 A0A060YZB6 (/ISS) A8KCK1 (/ISS) B7SVJ4 (/ISS) Q1A3D7 (/ISS) Q5U778 (/ISS) Q6XQG6 (/ISS) Q70I18 (/ISS)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
7 A0A060YZB6 (/ISS) A8KCK1 (/ISS) B7SVJ4 (/ISS) Q1A3D7 (/ISS) Q5U778 (/ISS) Q6XQG6 (/ISS) Q70I18 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
6 A0A060YZB6 (/ISS) A8KCK1 (/ISS) B7SVJ4 (/ISS) Q1A3D7 (/ISS) Q5U778 (/ISS) Q6XQG6 (/ISS)
Negative regulation of viral process GO:0048525
Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant.
5 Q1A3D7 (/IMP) Q6SR85 (/IMP) Q6SR85 (/IMP) Q6XQG6 (/IMP) Q6XQG7 (/IMP)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
5 A8KCK1 (/IMP) P0DMS7 (/IMP) Q5U778 (/IMP) Q6XQG7 (/IMP) Q70I18 (/IMP)
Cellular response to virus GO:0098586
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
4 A8E0J6 (/IDA) B6UQB1 (/IDA) Q70G08 (/IDA) Q70I18 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 Q1A3D7 (/IMP) Q6XQG6 (/IMP) Q6XQG7 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q70G08 (/IDA) Q70I18 (/IDA)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 Q1A3D7 (/IMP) Q6XQG6 (/IMP)
Negative regulation of viral process GO:0048525
Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant.
2 Q70G08 (/IDA) Q70I18 (/IDA)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 Q1A3D7 (/IMP) Q6XQG6 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P0DMS7 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q6XQG7 (/IMP)
Negative regulation of cell killing GO:0031342
Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing.
1 Q6XQG7 (/IDA)
Negative regulation of cell killing GO:0031342
Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing.
1 Q6XQG7 (/IMP)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 Q6XQG7 (/IDA)
Negative regulation of cytolysis GO:0045918
Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis.
1 Q6XQG7 (/IDA)
Negative regulation of cytolysis GO:0045918
Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis.
1 Q6XQG7 (/IMP)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
1 Q6XQG7 (/IMP)
Immune response involved in response to exogenous dsRNA GO:1902615
Any immune response that is involved in response to exogenous dsRNA.
1 Q6XQG7 (/IMP)
Negative regulation of viral translation GO:1904972
Any process that stops, prevents or reduces the frequency, rate or extent of viral translation.
1 Q6XQG7 (/IDA)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P0DMS7 (/IDA) Q70I18 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 P0DMS7 (/IDA) Q70I18 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q6XQG7 (/IDA)
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