The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28: Granulocyte-macrophage colony-stimulating factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
9 O62757 (/ISS) P11052 (/ISS) P28773 (/ISS) P48749 (/ISS) P51748 (/ISS) Q0MUT8 (/ISS) Q0MUT8 (/ISS) Q29118 (/ISS) Q60481 (/ISS)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
4 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA) P48750 (/IDA)
Granulocyte macrophage colony-stimulating factor receptor binding GO:0005129
Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor receptor.
3 P04141 (/TAS) P04141 (/TAS) P04141 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P04141 (/IPI) P04141 (/IPI) P04141 (/IPI)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dendritic cell differentiation GO:0097028
The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
4 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA) P48750 (/IDA)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
3 P04141 (/TAS) P04141 (/TAS) P04141 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Positive regulation of macrophage derived foam cell differentiation GO:0010744
Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P04141 (/TAS) P04141 (/TAS) P04141 (/TAS)
Macrophage differentiation GO:0030225
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Positive regulation of interleukin-23 production GO:0032747
Any process that activates or increases the frequency, rate, or extent of interleukin-23 production.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Myeloid dendritic cell differentiation GO:0043011
The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Regulation of myeloid cell differentiation GO:0045637
Any process that modulates the frequency, rate or extent of myeloid cell differentiation.
3 P04141 (/TAS) P04141 (/TAS) P04141 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Negative regulation of cytolysis GO:0045918
Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Positive regulation of podosome assembly GO:0071803
Any process that activates or increases the rate or extent of podosome assembly.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
2 I3L8Q3 (/IMP) Q29118 (/IMP)
TOR signaling GO:0031929
A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
2 I3L8Q3 (/IMP) Q29118 (/IMP)
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
2 I3L8Q3 (/IMP) Q29118 (/IMP)
ERK1 and ERK2 cascade GO:0070371
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2 I3L8Q3 (/IMP) Q29118 (/IMP)
Interferon-tau production GO:0072651
The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 I3L8Q3 (/IMP) Q29118 (/IMP)
Positive regulation of trophectodermal cell proliferation GO:1904075
Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation.
2 I3L8Q3 (/IMP) Q29118 (/IMP)
Histamine secretion GO:0001821
The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.
1 P48750 (/IDA)
Response to silicon dioxide GO:0034021
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus.
1 P48750 (/IEP)
Response to fluid shear stress GO:0034405
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
1 P48750 (/IEP)
Epithelial fluid transport GO:0042045
The directed movement of fluid across epithelia.
1 P48750 (/IDA)
Macrophage activation GO:0042116
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 P48750 (/IMP)
Regulation of circadian sleep/wake cycle, sleep GO:0045187
Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
1 P48750 (/IMP)
Positive regulation of macrophage differentiation GO:0045651
Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
1 P48750 (/TAS)
Epithelial cell proliferation GO:0050673
The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
1 P48750 (/TAS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P48750 (/IEP)
Interferon-tau production GO:0072651
The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
1 P11052 (/ISS)
Positive regulation of trophectodermal cell proliferation GO:1904075
Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation.
1 P11052 (/ISS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
9 O62757 (/ISS) P11052 (/ISS) P28773 (/ISS) P48749 (/ISS) P51748 (/ISS) Q0MUT8 (/ISS) Q0MUT8 (/ISS) Q29118 (/ISS) Q60481 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA) P48750 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P04141 (/TAS) P04141 (/TAS) P04141 (/TAS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
3 P04141 (/IDA) P04141 (/IDA) P04141 (/IDA)
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