The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: ciliary neurotrophic factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
2 P51642 (/ISO) P51642 (/ISO)
Ciliary neurotrophic factor receptor binding GO:0005127
Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor.
2 P51642 (/ISO) P51642 (/ISO)
Interleukin-6 receptor binding GO:0005138
Interacting selectively and non-covalently with the interleukin-6 receptor.
2 P51642 (/ISO) P51642 (/ISO)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
2 P51642 (/ISO) P51642 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 P51642 (/ISO) P51642 (/ISO)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
1 P20294 (/IDA)
Ciliary neurotrophic factor receptor binding GO:0005127
Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor.
1 P20294 (/IPI)
Ciliary neurotrophic factor receptor binding GO:0005127
Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor.
1 P26441 (/TAS)
Interleukin-6 receptor binding GO:0005138
Interacting selectively and non-covalently with the interleukin-6 receptor.
1 P26441 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P26441 (/IPI)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
1 P26441 (/IDA)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
1 P20294 (/TAS)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P26441 (/IPI)

There are 47 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
4 P20294 (/IDA) P26441 (/IDA) P51642 (/IDA) P51642 (/IDA)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
2 P51642 (/ISO) P51642 (/ISO)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
2 P51642 (/ISO) P51642 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P51642 (/IGI) P51642 (/IGI)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P51642 (/ISO) P51642 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P51642 (/ISO) P51642 (/ISO)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
2 P51642 (/ISO) P51642 (/ISO)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 P51642 (/ISO) P51642 (/ISO)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
2 P51642 (/ISO) P51642 (/ISO)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
2 P51642 (/ISO) P51642 (/ISO)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
2 P20294 (/IDA) P26441 (/IDA)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
2 P51642 (/ISO) P51642 (/ISO)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
2 P51642 (/ISO) P51642 (/ISO)
Negative regulation of photoreceptor cell differentiation GO:0046533
Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.
2 P51642 (/IDA) P51642 (/IDA)
Regulation of retinal cell programmed cell death GO:0046668
Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina.
2 P51642 (/IDA) P51642 (/IDA)
Positive regulation of hormone secretion GO:0046887
Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.
2 P51642 (/ISO) P51642 (/ISO)
Astrocyte activation GO:0048143
A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2 P51642 (/ISO) P51642 (/ISO)
Muscle organ morphogenesis GO:0048644
The process in which the anatomical structures of muscle are generated and organized.
2 P51642 (/IGI) P51642 (/IGI)
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
2 P51642 (/IGI) P51642 (/IGI)
Positive regulation of axon regeneration GO:0048680
Any process that activates, maintains or increases the rate of axon regeneration.
2 P51642 (/ISO) P51642 (/ISO)
Positive regulation of axon extension involved in regeneration GO:0048691
Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
2 P51642 (/ISO) P51642 (/ISO)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 P51642 (/ISO) P51642 (/ISO)
Regulation of resting membrane potential GO:0060075
Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized.
2 P51642 (/ISO) P51642 (/ISO)
Membrane hyperpolarization GO:0060081
The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
2 P51642 (/ISO) P51642 (/ISO)
Ciliary neurotrophic factor-mediated signaling pathway GO:0070120
A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P51642 (/ISO) P51642 (/ISO)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
2 P51642 (/ISO) P51642 (/ISO)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P26441 (/NAS)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
1 P20294 (/IDA)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 P20294 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P20294 (/IDA)
Response to light intensity GO:0009642
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.
1 P20294 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P26441 (/IDA)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 P20294 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P26441 (/TAS)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 P20294 (/IDA)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 P20294 (/IDA)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
1 P20294 (/IDA)
Positive regulation of hormone secretion GO:0046887
Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.
1 P20294 (/IDA)
Astrocyte activation GO:0048143
A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 P20294 (/IDA)
Positive regulation of axon regeneration GO:0048680
Any process that activates, maintains or increases the rate of axon regeneration.
1 P20294 (/IDA)
Positive regulation of axon extension involved in regeneration GO:0048691
Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
1 P20294 (/IDA)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P20294 (/IPI)
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
1 P20294 (/IEP)
Regulation of resting membrane potential GO:0060075
Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized.
1 P20294 (/IDA)
Membrane hyperpolarization GO:0060081
The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
1 P20294 (/IDA)
Ciliary neurotrophic factor-mediated signaling pathway GO:0070120
A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P26441 (/IDA)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P20294 (/IDA)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P51642 (/IDA) P51642 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P51642 (/ISO) P51642 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P51642 (/ISO) P51642 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 P51642 (/ISO) P51642 (/ISO)
Plasma membrane bounded cell projection cytoplasm GO:0032838
All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.
2 P51642 (/ISO) P51642 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P51642 (/ISO) P51642 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P26441 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P26441 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P20294 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P20294 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P20294 (/IDA)
Plasma membrane bounded cell projection cytoplasm GO:0032838
All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.
1 P20294 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P20294 (/IDA)
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