CATH Superfamily 1.20.1250.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 12: Growth hormone 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P01241 (/IPI) P01241 (/IPI) P0DML2 (/IPI) P0DML2 (/IPI) |
|
Growth hormone receptor binding GO:0005131
Interacting selectively and non-covalently with the growth hormone receptor.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Growth hormone receptor binding GO:0005131
Interacting selectively and non-covalently with the growth hormone receptor.
|
2 | P01241 (/IPI) P01241 (/IPI) |
|
Prolactin receptor binding GO:0005148
Interacting selectively and non-covalently with the prolactin receptor.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Prolactin receptor binding GO:0005148
Interacting selectively and non-covalently with the prolactin receptor.
|
2 | P01241 (/IPI) P01241 (/IPI) |
|
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
|
2 | P01242 (/TAS) P01242 (/TAS) |
|
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
|
2 | P01241 (/IPI) P01241 (/IPI) |
|
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
|
1 | Q14406 (/NAS) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Growth hormone receptor signaling pathway via JAK-STAT GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
|
6 | P01241 (/TAS) P01241 (/TAS) P01242 (/TAS) P01242 (/TAS) P0DML2 (/TAS) P0DML2 (/TAS) |
|
Positive regulation of activation of Janus kinase activity GO:0010536
Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Positive regulation of glucose transmembrane transport GO:0010828
Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
2 | P01241 (/IMP) P01241 (/IMP) |
|
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
|
2 | P01241 (/TAS) P01241 (/TAS) |
|
Positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568
Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Growth hormone receptor signaling pathway GO:0060396
The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Bone maturation GO:0070977
A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state.
|
2 | P01241 (/IDA) P01241 (/IDA) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
6 | P01241 (/TAS) P01241 (/TAS) P01242 (/TAS) P01242 (/TAS) P0DML2 (/TAS) P0DML2 (/TAS) |
|
Endosome lumen GO:0031904
The volume enclosed by the membrane of an endosome.
|
6 | P01241 (/TAS) P01241 (/TAS) P01242 (/TAS) P01242 (/TAS) P0DML2 (/TAS) P0DML2 (/TAS) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
4 | P0DML2 (/IDA) P0DML2 (/IDA) P0DML3 (/IDA) P0DML3 (/IDA) |
|
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
|
4 | P0DML2 (/IDA) P0DML2 (/IDA) P0DML3 (/IDA) P0DML3 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P01241 (/IDA) P01241 (/IDA) |
|
Growth hormone receptor complex GO:0070195
A receptor complex that consists of two identical subunits and binds growth hormone.
|
2 | P01241 (/IDA) P01241 (/IDA) |
