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CATH Superfamily 1.20.1220.12

Malate synthase, domain III

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Malate synthase, domain III
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Malate synthase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Malate synthase. [EC: 2.3.3.9]
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
  • The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate.
  • Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2).
  • Formerly EC 4.1.3.2.
 197 A0A070SKF0 A0A070SKF0 A0A070SKF0 A0A070SKF0 A0A070SKF0 A0A070SKF0 A0A070SKF0 A0A070SKF0 A0A070SKF0 A0A070SKF0
(187 more...)
Isocitrate lyase. [EC: 4.1.3.1]
Isocitrate = succinate + glyoxylate.
  • The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3- tricarboxylate.
 1 Q10663
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