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CATH Superfamily 1.20.120.1630

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Steroid 5 alpha-reductase 1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). [EC: 1.3.1.22]
A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH.
  • The enzyme catalyzes the conversion of assorted 3-oxo-Delta(4) steroids into their corresponding 5-alpha form.
  • Substrates for the mammalian enzyme include testosterone, progesterone, and corticosterone.
  • Substrates for the plant enzyme are brassinosteroids such as campest- 4-en-3-one and (22-alpha)-hydroxy-campest-4-en-3-one.
  • Cf. EC 1.3.99.5.
  • Formerly EC 1.3.1.4 and EC 1.3.1.30.
 26 A0A0A1ES47 A0A0A1ES47 A0A178VNR4 A0A178VNR4 A0A2R9BNM1 A0A2R9BNM1 A0A2R9BNM1 A5PJS2 H2QQM0 H2QQM0
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