The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Calcium-transporting ATPase, transmembrane domain
".
FunFam 13: Calcium-transporting ATPase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Calcium transmembrane transporter activity, phosphorylative mechanism GO:0005388
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).
|
5 | F5GU98 (/IDA) G5EC04 (/IDA) G5EC39 (/IDA) G5EFR6 (/IDA) Q64542 (/IDA) |
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
|
4 | F5GU98 (/IDA) G5EC04 (/IDA) G5EC39 (/IDA) G5EFR6 (/IDA) |
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
2 | Q00804 (/ISS) Q98SH2 (/ISS) |
Calcium transmembrane transporter activity, phosphorylative mechanism GO:0005388
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).
|
1 | Q64542 (/IC) |
Calcium transmembrane transporter activity, phosphorylative mechanism GO:0005388
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).
|
1 | B7CED8 (/ISS) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q64542 (/IPI) |
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
1 | Q64542 (/IPI) |
There are 29 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
|
7 | E6EK15 (/IMP) E6EK17 (/IMP) E6EK18 (/IMP) Q59DP8 (/IMP) Q59DP9 (/IMP) Q59DQ0 (/IMP) Q9V4C7 (/IMP) |
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
5 | F5GU98 (/IDA) G5EC04 (/IDA) G5EC39 (/IDA) G5EFR6 (/IDA) Q64542 (/IDA) |
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
|
4 | B7CED8 (/IMP) Q8MXS0 (/IMP) Q95XP5 (/IMP) Q95XP6 (/IMP) |
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
4 | B7CED8 (/IMP) Q8MXS0 (/IMP) Q95XP5 (/IMP) Q95XP6 (/IMP) |
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
|
4 | F5GU98 (/IDA) G5EC04 (/IDA) G5EC39 (/IDA) G5EFR6 (/IDA) |
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
|
4 | B7CED8 (/IMP) Q8MXS0 (/IMP) Q95XP5 (/IMP) Q95XP6 (/IMP) |
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
|
4 | B7CED8 (/IMP) Q8MXS0 (/IMP) Q95XP5 (/IMP) Q95XP6 (/IMP) |
Positive regulation of growth rate GO:0040010
Any process that increases the rate of growth of all or part of an organism.
|
4 | B7CED8 (/IMP) Q8MXS0 (/IMP) Q95XP5 (/IMP) Q95XP6 (/IMP) |
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
|
4 | B7CED8 (/IMP) Q8MXS0 (/IMP) Q95XP5 (/IMP) Q95XP6 (/IMP) |
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
|
4 | B7CED8 (/IMP) Q8MXS0 (/IMP) Q95XP5 (/IMP) Q95XP6 (/IMP) |
Negative regulation of cytosolic calcium ion concentration GO:0051481
Any process that decreases the concentration of calcium ions in the cytosol.
|
4 | B7CED8 (/IMP) Q8MXS0 (/IMP) Q95XP5 (/IMP) Q95XP6 (/IMP) |
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
|
2 | Q00804 (/ISS) Q64542 (/ISS) |
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
|
2 | Q00804 (/ISS) Q98SH2 (/ISS) |
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
|
1 | Q00804 (/ISS) |
Regulation of vascular smooth muscle contraction GO:0003056
Any process that increases the frequency, rate or extent of vascular smooth muscle contraction.
|
1 | Q00804 (/ISS) |
Neural retina development GO:0003407
The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
|
1 | Q64542 (/IEP) |
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | Q64542 (/IEP) |
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
|
1 | Q00804 (/ISS) |
Urinary bladder smooth muscle contraction GO:0014832
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.
|
1 | Q64542 (/ISS) |
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
|
1 | Q64542 (/IEP) |
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
|
1 | Q64542 (/ISS) |
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
|
1 | Q00804 (/ISS) |
Negative regulation of cytosolic calcium ion concentration GO:0051481
Any process that decreases the concentration of calcium ions in the cytosol.
|
1 | Q00804 (/ISS) |
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q00804 (/ISS) |
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
1 | Q64542 (/IMP) |
Negative regulation of calcineurin-NFAT signaling cascade GO:0070885
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
|
1 | Q64542 (/IMP) |
Regulation of cellular response to insulin stimulus GO:1900076
Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.
|
1 | Q00804 (/ISS) |
Calcium ion export GO:1901660
The directed movement of calcium ion out of a cell or organelle.
|
1 | Q64542 (/IMP) |
Cellular response to acetylcholine GO:1905145
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus.
|
1 | Q64542 (/ISS) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | E6EK15 (/HDA) E6EK17 (/HDA) E6EK18 (/HDA) Q59DP8 (/HDA) Q59DP9 (/HDA) Q59DQ0 (/HDA) Q9V4C7 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | B7CED8 (/IDA) E7ERY9 (/IDA) E7ERY9 (/IDA) E7ERY9 (/IDA) Q8MXS0 (/IDA) Q95XP5 (/IDA) Q95XP6 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
4 | F5GU98 (/IDA) G5EC04 (/IDA) G5EC39 (/IDA) G5EFR6 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | E7ERY9 (/IDA) E7ERY9 (/IDA) E7ERY9 (/IDA) |
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
|
1 | Q00804 (/ISS) |
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | Q64542 (/IDA) |
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | Q00804 (/ISS) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q64542 (/IDA) |
Sperm principal piece GO:0097228
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
|
1 | Q64542 (/IDA) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | Q64542 (/EXP) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | Q64542 (/IDA) |
Integral component of presynaptic active zone membrane GO:0099059
The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q64542 (/EXP) |
Integral component of presynaptic active zone membrane GO:0099059
The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q64542 (/IDA) |