The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Calcium-transporting ATPase, transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Plasma membrane ATPase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proton-exporting ATPase activity, phosphorylative mechanism GO:0008553
Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.
5 A0A1D8PJ01 (/IDA) P05030 (/IDA) P05030 (/IDA) P19657 (/IDA) P19657 (/IDA)
Proton-exporting ATPase activity, phosphorylative mechanism GO:0008553
Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.
3 G5EB90 (/ISA) G5EB90 (/ISA) G5EB90 (/ISA)
Proton-exporting ATPase activity, phosphorylative mechanism GO:0008553
Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.
3 G5EB90 (/RCA) G5EB90 (/RCA) G5EB90 (/RCA)
Proton-exporting ATPase activity, phosphorylative mechanism GO:0008553
Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.
2 P09627 (/IMP) P28876 (/IMP)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P28876 (/ISM)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 A0A1D8PJ01 (/IDA)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 P09627 (/IMP)
Proton binding GO:1901691
Interacting selectively and non-covalently with proton.
1 P09627 (/IDA)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of pH GO:0006885
Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
4 P05030 (/IEP) P05030 (/IEP) P19657 (/IEP) P19657 (/IEP)
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
4 P05030 (/IDA) P05030 (/IDA) P19657 (/IDA) P19657 (/IDA)
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
3 G5EB90 (/RCA) G5EB90 (/RCA) G5EB90 (/RCA)
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
3 G5EB90 (/ISA) G5EB90 (/ISA) G5EB90 (/ISA)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
2 P05030 (/IDA) P05030 (/IDA)
Proteasome storage granule assembly GO:1902906
The aggregation, arrangement and bonding together of a set of components to form a proteasome storage granule.
2 P05030 (/IMP) P05030 (/IMP)
Positive regulation of TORC1 signaling GO:1904263
Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
2 P05030 (/IMP) P05030 (/IMP)
Regulation of intracellular pH GO:0051453
Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
1 P09627 (/IMP)
Proton export across plasma membrane GO:0120029
The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region.
1 P09627 (/IMP)
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
1 Q4WWZ4 (/IMP)
Proton transmembrane transport GO:1902600
The directed movement of a proton across a membrane.
1 P28876 (/NAS)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 A0A1D8PJ01 (/IDA) P05030 (/IDA) P05030 (/IDA) P09627 (/IDA) P19657 (/IDA) P19657 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P05030 (/HDA) P05030 (/HDA) P19657 (/HDA) P19657 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P05030 (/HDA) P05030 (/HDA) P19657 (/HDA) P19657 (/HDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
3 A0A1D8PJ01 (/IDA) P05030 (/IDA) P05030 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P05030 (/HDA) P05030 (/HDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
2 P19657 (/HDA) P19657 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P09627 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 P09627 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P09627 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P28876 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P09627 (/IC)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 A0A1D8PJ01 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 A0A1D8PJ01 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P09627 (/IDA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 P28876 (/HDA)
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
1 P28876 (/HDA)
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