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CATH Superfamily 1.20.1090.10

Dehydroquinate synthase-like - alpha domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dehydroquinate synthase-like - alpha domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Aldehyde-alcohol dehydrogenase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Alcohol dehydrogenase. [EC: 1.1.1.1]
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
 15327 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7
(15317 more...)
Acetaldehyde dehydrogenase (acetylating). [EC: 1.2.1.10]
Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH.
  • Also acts, more slowly, on glycolaldehyde, propanal and butanal.
  • In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39.
  • The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87.
  • Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols.
  • NADP(+) can replace NAD(+) but the rate of reaction is much slower.
 15007 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7 A0A023YWD7
(14997 more...)
Lactaldehyde reductase. [EC: 1.1.1.77]
(1) (R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + NADH. (2) (S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + NADH.
    		 3906 A0A025CVW8 A0A025CVW8 A0A025CVW8 A0A025CVW8 A0A025CVW8 A0A025CVW8 A0A025CVW8 A0A025CVW8 A0A025CVW8 A0A025CVW8
    (3896 more...)
    1,3-propanediol dehydrogenase. [EC: 1.1.1.202]
    Propane-1,3-diol + NAD(+) = 3-hydroxypropanal + NADH.
      		 168 A0A0E1C832 A0A0E1C832 A0A0E1C832 A0A0E1C832 A0A0E1C832 A0A0E1C832 A0A0E1C832 A0A0E1C832 A0A0E1C832 A0A0E1C832
      (158 more...)
      Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
      An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
      • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
      • Formerly EC 1.1.1.70.
      		 9 A0A0K2A0G4 A0A0K2A0G4 A0A0K2A0G4 A0A2P8MA19 A0A2P8MA19 A0A2P8MA19 P33744 P33744 P33744
      Methanol dehydrogenase. [EC: 1.1.1.244]
      Methanol + NAD(+) = formaldehyde + NADH.
        		 1 P31005
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