The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glycerol uptake facilitator protein.
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: aquaporin-4 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
6 P47863 (/IDA) P55087 (/IDA) P55087 (/IDA) P55088 (/IDA) Q9V5Z7 (/IDA) Q9V5Z7 (/IDA)
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
6 O77750 (/ISS) Q5I4F9 (/ISS) Q923J4 (/ISS) Q923J4 (/ISS) Q9V5Z7 (/ISS) Q9V5Z7 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P47863 (/IPI) P55087 (/IPI) P55087 (/IPI) P55088 (/IPI)
Water transmembrane transporter activity GO:0005372
Enables the transfer of water (H2O) from one side of a membrane to the other.
2 A0A2R8Q5A8 (/IDA) Q6AZD2 (/IDA)
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2 P55087 (/EXP) P55087 (/EXP)
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 P55088 (/ISO)
Porin activity GO:0015288
Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
1 P47863 (/IDA)
Porin activity GO:0015288
Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
1 P55088 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P55088 (/ISO)

There are 50 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular water homeostasis GO:0009992
Any process involved in the maintenance of an internal steady state of water within a cell.
7 O77750 (/ISS) P47863 (/ISS) P55087 (/ISS) P55087 (/ISS) Q5I4F9 (/ISS) Q923J4 (/ISS) Q923J4 (/ISS)
Water homeostasis GO:0030104
Any process involved in the maintenance of an internal steady state of water within an organism or cell.
7 O77750 (/ISS) P47863 (/ISS) P55087 (/ISS) P55087 (/ISS) Q5I4F9 (/ISS) Q923J4 (/ISS) Q923J4 (/ISS)
Cerebrospinal fluid circulation GO:0090660
The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional.
7 O77750 (/ISS) P47863 (/ISS) P55087 (/ISS) P55087 (/ISS) Q5I4F9 (/ISS) Q923J4 (/ISS) Q923J4 (/ISS)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 P47863 (/IDA) P55087 (/IDA) P55087 (/IDA) P55088 (/IDA) Q9V5Z7 (/IDA) Q9V5Z7 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
5 O77750 (/ISS) P55088 (/ISS) Q5I4F9 (/ISS) Q923J4 (/ISS) Q923J4 (/ISS)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 O77750 (/ISS) Q5I4F9 (/ISS) Q923J4 (/ISS) Q923J4 (/ISS)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P55087 (/TAS) P55087 (/TAS) P55088 (/TAS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
3 P47863 (/IDA) P55087 (/IDA) P55087 (/IDA)
Renal system process GO:0003014
A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
2 Q9V5Z7 (/IEP) Q9V5Z7 (/IEP)
Renal water homeostasis GO:0003091
Renal process involved in the maintenance of an internal steady state of water in the body.
2 P55087 (/TAS) P55087 (/TAS)
Water homeostasis GO:0030104
Any process involved in the maintenance of an internal steady state of water within an organism or cell.
2 Q9V5Z7 (/IEP) Q9V5Z7 (/IEP)
Regulation of oviposition GO:0046662
Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium.
2 Q9V5Z7 (/IMP) Q9V5Z7 (/IMP)
Multicellular organismal water homeostasis GO:0050891
Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
2 P55087 (/IEP) P55087 (/IEP)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
2 Q9V5Z7 (/IDA) Q9V5Z7 (/IDA)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
2 P55087 (/IDA) P55087 (/IDA)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P55088 (/IMP)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P55088 (/ISO)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 P47863 (/IEP)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 P55088 (/IMP)
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
1 P47863 (/IEP)
Cellular water homeostasis GO:0009992
Any process involved in the maintenance of an internal steady state of water within a cell.
1 P55088 (/IDA)
Regulation of vascular endothelial growth factor production GO:0010574
Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.
1 P47863 (/IMP)
Regulation of vascular endothelial growth factor production GO:0010574
Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.
1 P55088 (/ISO)
Carbon dioxide transport GO:0015670
The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P47863 (/IDA)
Carbon dioxide transport GO:0015670
The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P55088 (/ISO)
Water homeostasis GO:0030104
Any process involved in the maintenance of an internal steady state of water within an organism or cell.
1 P55088 (/IDA)
Water homeostasis GO:0030104
Any process involved in the maintenance of an internal steady state of water within an organism or cell.
1 P55088 (/IMP)
Water homeostasis GO:0030104
Any process involved in the maintenance of an internal steady state of water within an organism or cell.
1 P55088 (/NAS)
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
1 P47863 (/IMP)
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
1 P55088 (/ISO)
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
1 P47863 (/IMP)
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
1 P55088 (/ISO)
Hyperosmotic salinity response GO:0042538
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 P47863 (/IEP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P47863 (/IDA)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P55088 (/ISO)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P55088 (/ISO)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P47863 (/IEP)
Negative regulation of cell adhesion molecule production GO:0060354
Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.
1 P47863 (/IMP)
Negative regulation of cell adhesion molecule production GO:0060354
Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.
1 P55088 (/ISO)
Renal water absorption GO:0070295
A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
1 P55088 (/IGI)
Renal water absorption GO:0070295
A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
1 P55088 (/IMP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P47863 (/IMP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P55088 (/ISO)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
1 P55088 (/ISO)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 P47863 (/IEP)
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
1 P47863 (/IEP)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P47863 (/IEP)
Cerebrospinal fluid circulation GO:0090660
The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional.
1 P55088 (/IMP)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 P47863 (/IMP)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 P55088 (/ISO)

There are 33 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
6 O77750 (/ISS) P55087 (/ISS) P55087 (/ISS) Q5I4F9 (/ISS) Q923J4 (/ISS) Q923J4 (/ISS)
Astrocyte end-foot GO:0097450
Terminal process of astrocyte abutting non-neuronal surfaces in the brain.
6 O77750 (/ISS) P55087 (/ISS) P55087 (/ISS) Q5I4F9 (/ISS) Q923J4 (/ISS) Q923J4 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P47863 (/IDA) P55087 (/IDA) P55087 (/IDA) P55088 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 O77750 (/ISS) Q5I4F9 (/ISS) Q923J4 (/ISS) Q923J4 (/ISS)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
4 P47863 (/IDA) P55087 (/IDA) P55087 (/IDA) P55088 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
4 O77750 (/ISS) Q5I4F9 (/ISS) Q923J4 (/ISS) Q923J4 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P55087 (/IDA) P55087 (/IDA) P55088 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P55087 (/IDA) P55087 (/IDA) P55088 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P55087 (/TAS) P55087 (/TAS)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
2 P55087 (/IDA) P55087 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9V5Z7 (/IDA) Q9V5Z7 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 P47863 (/IDA) P55088 (/IDA)
Astrocyte end-foot GO:0097450
Terminal process of astrocyte abutting non-neuronal surfaces in the brain.
2 P47863 (/IDA) P55088 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P55088 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P55088 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P55088 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P55088 (/TAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 P55088 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 P55088 (/ISO)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 P47863 (/IDA)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 P55088 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P47863 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P55088 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P55088 (/NAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 P55088 (/ISO)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 P47863 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 P55088 (/ISO)
Cell projection membrane GO:0031253
The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
1 P47863 (/IDA)
Cell projection membrane GO:0031253
The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
1 P55088 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P47863 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P55088 (/ISO)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 P55088 (/ISO)
Astrocyte end-foot GO:0097450
Terminal process of astrocyte abutting non-neuronal surfaces in the brain.
1 P55088 (/ISO)
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