The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glycerol uptake facilitator protein.
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 41: Aquaglyceroporin 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
9 Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I6 (/IMP) Q4Q6R2 (/IMP) Q585Q8 (/IMP) Q585Q8 (/IMP)
Glycerol channel activity GO:0015254
Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
9 Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I6 (/IMP) Q4Q6R2 (/IMP) Q585Q8 (/IMP) Q585Q8 (/IMP)
Water transmembrane transporter activity GO:0005372
Enables the transfer of water (H2O) from one side of a membrane to the other.
5 Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA)
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
5 Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
1 Q4Q6R2 (/IDA)
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
1 Q4Q6R2 (/IMP)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glycerol transport GO:0015793
The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
9 Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I6 (/IMP) Q4Q6R2 (/IMP) Q585Q8 (/IMP) Q585Q8 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
7 Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I5 (/IMP) Q388I6 (/IMP) Q4Q6R2 (/IMP)
Drug transmembrane transport GO:0006855
The process in which a drug is transported across a membrane.
1 Q4Q6R2 (/IMP)
Hypotonic response GO:0006971
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
1 Q4Q6R2 (/IMP)
Response to metal ion GO:0010038
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
1 Q4Q6R2 (/IDA)
Detection of osmotic stimulus GO:0043575
The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal.
1 Q4Q6R2 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I6 (/IDA) Q4Q6R2 (/IDA) Q585Q8 (/IDA) Q585Q8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I6 (/IDA)
Ciliary pocket GO:0020016
Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes.
5 Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA) Q388I5 (/IDA)
Contractile vacuole GO:0000331
A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory.
1 Q4Q6R2 (/IMP)
Ciliary pocket GO:0020016
Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes.
1 Q4Q6R2 (/IMP)
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
1 Q4Q6R2 (/IMP)
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