The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glycerol uptake facilitator protein.
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Probable aquaporin TIP1-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
6 O64964 (/IDA) O64964 (/IDA) O64964 (/IDA) O82598 (/IDA) P25818 (/IDA) Q41951 (/IDA)
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
5 O64964 (/TAS) O64964 (/TAS) O64964 (/TAS) Q9ATM0 (/TAS) Q9ATM0 (/TAS)
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
4 O82598 (/ISS) Q41963 (/ISS) Q41963 (/ISS) Q41963 (/ISS)
Methylammonium transmembrane transporter activity GO:0015200
Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other.
2 Q41951 (/IDA) Q9FGL2 (/IDA)
Urea transmembrane transporter activity GO:0015204
Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
1 O82598 (/IDA)
Urea transmembrane transporter activity GO:0015204
Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
1 P25818 (/IGI)
Urea transmembrane transporter activity GO:0015204
Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
1 B1NHU1 (/ISO)
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 B1NHU1 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q41951 (/IPI)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hydrogen peroxide transmembrane transport GO:0080170
The process in which hydrogen peroxide is transported across a membrane.
4 P25818 (/IDA) Q41963 (/IDA) Q41963 (/IDA) Q41963 (/IDA)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 O82598 (/IDA) P25818 (/IDA) Q41951 (/IDA)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 O64964 (/IMP) O64964 (/IMP) O64964 (/IMP)
Vacuole organization GO:0007033
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
3 O64964 (/TAS) O64964 (/TAS) O64964 (/TAS)
Unidimensional cell growth GO:0009826
The process in which a cell irreversibly increases in size in one
3 O64964 (/IEP) O64964 (/IEP) O64964 (/IEP)
Water homeostasis GO:0030104
Any process involved in the maintenance of an internal steady state of water within an organism or cell.
3 Q41963 (/IDA) Q41963 (/IDA) Q41963 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
3 Q41963 (/IEP) Q41963 (/IEP) Q41963 (/IEP)
Leaf development GO:0048366
The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.
3 O64964 (/IEP) O64964 (/IEP) O64964 (/IEP)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
2 P26587 (/TAS) P26587 (/TAS)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 B1NHU1 (/ISO)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q39882 (/RCA)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9XG70 (/TAS)
Seed maturation GO:0010431
A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination.
1 P23958 (/TAS)
Glycerol transport GO:0015793
The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
1 Q39882 (/RCA)
Glycerol transport GO:0015793
The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
1 Q9XG70 (/TAS)
Urea transport GO:0015840
The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.
1 O82598 (/IDA)
Urea transport GO:0015840
The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.
1 P25818 (/IGI)
Urea transport GO:0015840
The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.
1 Q9ATL3 (/IMP)
Urea transport GO:0015840
The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.
1 B1NHU1 (/ISO)
Urea transport GO:0015840
The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.
1 Q9XG70 (/TAS)
Urea transmembrane transport GO:0071918
The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 B1NHU1 (/ISO)
Hydrogen peroxide transmembrane transport GO:0080170
The process in which hydrogen peroxide is transported across a membrane.
1 B1NHU1 (/ISO)
Seed trichome elongation GO:0090378
The process in which a seed trichome irreversibly increases in size in one
1 B1NHU1 (/IEP)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
20 O64964 (/TAS) O64964 (/TAS) O64964 (/TAS) Q39882 (/TAS) Q84RL6 (/TAS) Q84RL6 (/TAS) Q84RL6 (/TAS) Q9ATL3 (/TAS) Q9ATL4 (/TAS) Q9ATL5 (/TAS)
(10 more)
Plant-type vacuole membrane GO:0009705
The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.
12 O64964 (/IDA) O64964 (/IDA) O64964 (/IDA) O82316 (/IDA) O82316 (/IDA) P25818 (/IDA) P26587 (/IDA) P26587 (/IDA) Q41951 (/IDA) Q41975 (/IDA)
(2 more)
Protein storage vacuole membrane GO:0032586
The lipid bilayer surrounding a protein storage vacuole.
10 Q84RL6 (/TAS) Q84RL6 (/TAS) Q84RL6 (/TAS) Q9ATL7 (/TAS) Q9ATL7 (/TAS) Q9ATL7 (/TAS) Q9ATL8 (/TAS) Q9ATL8 (/TAS) Q9ATL9 (/TAS) Q9ATL9 (/TAS)
Central vacuole GO:0042807
A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination.
9 O82316 (/IDA) O82316 (/IDA) P25818 (/IDA) P26587 (/IDA) P26587 (/IDA) Q41951 (/IDA) Q41975 (/IDA) Q41975 (/IDA) Q9FGL2 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
7 P25818 (/IDA) Q41951 (/IDA) Q41963 (/IDA) Q41963 (/IDA) Q41963 (/IDA) Q41975 (/IDA) Q41975 (/IDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
7 P25818 (/IDA) Q41951 (/IDA) Q41963 (/IDA) Q41963 (/IDA) Q41963 (/IDA) Q41975 (/IDA) Q41975 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
6 Q41951 (/IDA) Q41963 (/IDA) Q41963 (/IDA) Q41963 (/IDA) Q41975 (/IDA) Q41975 (/IDA)
Protein storage vacuole GO:0000326
A storage vacuole that contains a lytic vacuole; identified in plants.
4 P25818 (/IDA) P26587 (/IDA) P26587 (/IDA) Q41951 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 Q41951 (/IDA) Q41963 (/IDA) Q41963 (/IDA) Q41963 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q41951 (/IDA) Q41963 (/IDA) Q41963 (/IDA) Q41963 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
3 Q41963 (/IDA) Q41963 (/IDA) Q41963 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q41963 (/IDA) Q41963 (/IDA) Q41963 (/IDA)
Columella GO:0043674
A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella).
3 Q41963 (/IDA) Q41963 (/IDA) Q41963 (/IDA)
Plant-type vacuole membrane GO:0009705
The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.
2 D8FSL1 (/ISA) D8FSL1 (/ISA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
2 P25818 (/IDA) Q41951 (/IDA)
Central vacuole GO:0042807
A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination.
2 D8FSL1 (/ISA) D8FSL1 (/ISA)
Protein storage vacuole GO:0000326
A storage vacuole that contains a lytic vacuole; identified in plants.
1 B1NHU1 (/ISO)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
1 Q41951 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 B1NHU1 (/ISO)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
1 B1NHU1 (/ISO)
Plant-type cell wall GO:0009505
A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.
1 Q41951 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 Q41951 (/IDA)
Plant-type vacuole membrane GO:0009705
The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.
1 B1NHU1 (/ISO)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 B1NHU1 (/ISO)
Central vacuole GO:0042807
A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination.
1 B1NHU1 (/ISO)
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