The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glycerol uptake facilitator protein.
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19: AQuaPorin or aquaglyceroporin related

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Water transmembrane transporter activity GO:0005372
Enables the transfer of water (H2O) from one side of a membrane to the other.
9 A0A2R8QLW2 (/IDA) A0A2R8QP87 (/IDA) A1L2B1 (/IDA) A7MCF8 (/IDA) A9ULS6 (/IDA) D3TI82 (/IDA) D3TZW5 (/IDA) D3U0R1 (/IDA) Q66I64 (/IDA)
Urea transmembrane transporter activity GO:0015204
Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
7 A0A2R8QLW2 (/IDA) A0A2R8QP87 (/IDA) A1L2B1 (/IDA) A7MCF8 (/IDA) D3TI82 (/IDA) D3TZW5 (/IDA) Q66I64 (/IDA)
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
7 C0HB60 (/IDA) D5MCS1 (/IDA) G5EEK0 (/IDA) H2FLH4 (/IDA) Q18352 (/IDA) S5R5I0 (/IDA) S5RRC8 (/IDA)
Urea channel activity GO:0015265
Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
3 C0HB60 (/IDA) S5R5I0 (/IDA) S5RRC8 (/IDA)
Glycerol channel activity GO:0015254
Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2 C0HB60 (/IDA) S5R5I0 (/IDA)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 D5MCS1 (/IDA) G5EEK0 (/IDA) H2FLH4 (/IDA) Q18352 (/IDA)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 S5R5I0 (/IDA)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 A0A060X7C2 (/IDA) A0A060Y2R1 (/IDA) G5EEK0 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
3 A0A060X7C2 (/IDA) A0A060Y2R1 (/IDA) S5RRC8 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
3 D5MCS1 (/IDA) H2FLH4 (/IDA) Q18352 (/IDA)
Non-motile cilium GO:0097730
A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.
3 D5MCS1 (/IDA) H2FLH4 (/IDA) Q18352 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 C0HB60 (/IDA) G5EEK0 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
2 C0HB60 (/IDA) S5R5I0 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 S5RRC8 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 S5R5I0 (/IDA)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
1 S5R5I0 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 S5R5I0 (/IDA)
Basolateral part of cell GO:1990794
The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells.
1 C0HB60 (/IDA)
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