The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Opsin, ultraviolet-sensitive

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
14 O01668 (/ISS) O01668 (/ISS) O01668 (/ISS) P04950 (/ISS) P06002 (/ISS) P06002 (/ISS) P08099 (/ISS) P08099 (/ISS) P08255 (/ISS) P08255 (/ISS)
(4 more)
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
14 O01668 (/NAS) O01668 (/NAS) O01668 (/NAS) P04950 (/NAS) P06002 (/NAS) P06002 (/NAS) P08099 (/NAS) P08099 (/NAS) P08255 (/NAS) P08255 (/NAS)
(4 more)
Photoreceptor activity GO:0009881
The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation.
9 A0A0R4IK89 (/IDA) A0A0R4ISV7 (/IDA) F1QZ18 (/IDA) G8Z413 (/IDA) O61303 (/IDA) Q1JPS6 (/IDA) Q1JPS6 (/IDA) Q401Q0 (/IDA) Q401Q1 (/IDA)
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
7 P04950 (/IDA) P08099 (/IDA) P08099 (/IDA) P08255 (/IDA) P08255 (/IDA) P08255 (/IDA) P08255 (/IDA)
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
7 P04950 (/TAS) P08099 (/TAS) P08099 (/TAS) P08255 (/TAS) P08255 (/TAS) P08255 (/TAS) P08255 (/TAS)
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
5 O01668 (/IGI) O01668 (/IGI) O01668 (/IGI) P91657 (/IGI) P91657 (/IGI)
Retinal binding GO:0016918
Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.
4 O16005 (/ISS) P09241 (/ISS) P24603 (/ISS) Q17094 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P06002 (/IPI) P06002 (/IPI)
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
2 P06002 (/IMP) P06002 (/IMP)
Photoreceptor activity GO:0009881
The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation.
1 B8Y5Y5 (/TAS)
Retinal binding GO:0016918
Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.
1 P31356 (/IDA)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
14 O01668 (/ISS) O01668 (/ISS) O01668 (/ISS) P04950 (/ISS) P06002 (/ISS) P06002 (/ISS) P08099 (/ISS) P08099 (/ISS) P08255 (/ISS) P08255 (/ISS)
(4 more)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
14 O01668 (/NAS) O01668 (/NAS) O01668 (/NAS) P04950 (/NAS) P06002 (/NAS) P06002 (/NAS) P08099 (/NAS) P08099 (/NAS) P08255 (/NAS) P08255 (/NAS)
(4 more)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
7 O01668 (/IGI) O01668 (/IGI) O01668 (/IGI) P08099 (/IGI) P08099 (/IGI) P91657 (/IGI) P91657 (/IGI)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
7 O01668 (/ISS) O01668 (/ISS) O01668 (/ISS) P06002 (/ISS) P06002 (/ISS) P91657 (/ISS) P91657 (/ISS)
Thermotaxis GO:0043052
The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.
7 O01668 (/IMP) O01668 (/IMP) O01668 (/IMP) P06002 (/IMP) P06002 (/IMP) P91657 (/IMP) P91657 (/IMP)
Phototransduction, UV GO:0007604
The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers.
5 P04950 (/IDA) P08255 (/IDA) P08255 (/IDA) P08255 (/IDA) P08255 (/IDA)
Phototransduction, UV GO:0007604
The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers.
5 P04950 (/NAS) P08255 (/NAS) P08255 (/NAS) P08255 (/NAS) P08255 (/NAS)
Phototransduction, UV GO:0007604
The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers.
5 P04950 (/TAS) P08255 (/TAS) P08255 (/TAS) P08255 (/TAS) P08255 (/TAS)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
5 O01668 (/IMP) O01668 (/IMP) O01668 (/IMP) P91657 (/IMP) P91657 (/IMP)
Detection of UV GO:0009589
The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
5 P04950 (/TAS) P08255 (/TAS) P08255 (/TAS) P08255 (/TAS) P08255 (/TAS)
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
5 O01668 (/IGI) O01668 (/IGI) O01668 (/IGI) P91657 (/IGI) P91657 (/IGI)
Cellular response to light stimulus GO:0071482
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
4 A9QM68 (/IMP) P06002 (/IMP) P06002 (/IMP) Q90YK6 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 O01668 (/IMP) O01668 (/IMP) O01668 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
3 F1QZ18 (/IDA) Q1JPS6 (/IDA) Q1JPS6 (/IDA)
Absorption of visible light GO:0016038
The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm.
3 G1N1Z2 (/ISS) R0LC04 (/ISS) U3I9F5 (/ISS)
Protein-chromophore linkage GO:0018298
The covalent or noncovalent attachment of a chromophore to a protein.
3 G1N1Z2 (/ISS) R0LC04 (/ISS) U3I9F5 (/ISS)
Cellular response to light stimulus GO:0071482
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
3 G1N1Z2 (/ISS) R0LC04 (/ISS) U3I9F5 (/ISS)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
2 P06002 (/IMP) P06002 (/IMP)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 P06002 (/IMP) P06002 (/IMP)
Light-induced release of internally sequestered calcium ion GO:0008377
The process in which the detection of light triggers the release of internally sequestered calcium ions.
2 Q1JPS6 (/IDA) Q1JPS6 (/IDA)
Photoreceptor cell morphogenesis GO:0008594
The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.
2 P06002 (/IMP) P06002 (/IMP)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
2 P91657 (/IDA) P91657 (/IDA)
Detection of visible light GO:0009584
The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
2 P06002 (/IMP) P06002 (/IMP)
UV-A, blue light phototransduction GO:0009588
The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm.
2 P91657 (/NAS) P91657 (/NAS)
Detection of UV GO:0009589
The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
2 P06002 (/IMP) P06002 (/IMP)
Response to light intensity GO:0009642
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.
2 P06002 (/IMP) P06002 (/IMP)
Absorption of visible light GO:0016038
The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm.
2 A9QM68 (/IDA) Q90YK6 (/IDA)
Absorption of visible light GO:0016038
The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm.
2 P91657 (/IMP) P91657 (/IMP)
Protein-chromophore linkage GO:0018298
The covalent or noncovalent attachment of a chromophore to a protein.
2 A9QM68 (/IDA) Q90YK6 (/IDA)
Phospholipase C-activating rhodopsin mediated signaling pathway GO:0030265
The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).
2 P06002 (/IMP) P06002 (/IMP)
Rhabdomere development GO:0042052
The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
2 P06002 (/IMP) P06002 (/IMP)
Phototaxis GO:0042331
The directed movement of a motile cell or organism in response to light.
2 P06002 (/IMP) P06002 (/IMP)
Negative regulation of compound eye retinal cell programmed cell death GO:0046673
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.
2 P06002 (/IMP) P06002 (/IMP)
Optomotor response GO:0071632
Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish.
2 P06002 (/IMP) P06002 (/IMP)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
1 B8Y5Y5 (/TAS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 B8Y5Y5 (/TAS)
Absorption of UV light GO:0016039
The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm.
1 P04950 (/IMP)
Luteinizing hormone secretion GO:0032275
The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary.
1 B8Y5Y5 (/TAS)
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
1 B8Y5Y5 (/TAS)
Detection of light stimulus involved in visual perception GO:0050908
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
1 P90680 (/IDA)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
18 O01668 (/ISS) O01668 (/ISS) O01668 (/ISS) O16005 (/ISS) P04950 (/ISS) P06002 (/ISS) P06002 (/ISS) P08099 (/ISS) P08099 (/ISS) P08255 (/ISS)
(8 more)
Rhabdomere GO:0016028
The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
7 O01668 (/IDA) O01668 (/IDA) O01668 (/IDA) P06002 (/IDA) P06002 (/IDA) P91657 (/IDA) P91657 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 G1N1Z2 (/ISS) R0LC04 (/ISS) U3I9F5 (/ISS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
3 G1N1Z2 (/ISS) R0LC04 (/ISS) U3I9F5 (/ISS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
3 G1N1Z2 (/ISS) R0LC04 (/ISS) U3I9F5 (/ISS)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
3 G1N1Z2 (/ISS) R0LC04 (/ISS) U3I9F5 (/ISS)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
2 A9QM68 (/IDA) Q90YK6 (/IDA)
Secondary lysosome GO:0005767
Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome.
2 P06002 (/IDA) P06002 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
2 P06002 (/IDA) P06002 (/IDA)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
2 P06002 (/IDA) P06002 (/IDA)
Rough endoplasmic reticulum GO:0005791
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
2 P06002 (/IDA) P06002 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 A9QM68 (/IDA) Q90YK6 (/IDA)
InaD signaling complex GO:0016027
A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.
2 P06002 (/IPI) P06002 (/IPI)
InaD signaling complex GO:0016027
A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.
2 P06002 (/TAS) P06002 (/TAS)
Subrhabdomeral cisterna GO:0016029
A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase.
2 P06002 (/IDA) P06002 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 A9QM68 (/IDA) Q90YK6 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 P06002 (/IDA) P06002 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 A9QM68 (/IDA) Q90YK6 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
2 A9QM68 (/IDA) Q90YK6 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P31356 (/IDA)
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