The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
VPS9 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: rab5 GDP/GTP exchange factor isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 O18973 (/IPI) Q9JM13 (/IPI) Q9UJ41 (/IPI) Q9UJ41 (/IPI) Q9UJ41 (/IPI) Q9UJ41 (/IPI)
Rab guanyl-nucleotide exchange factor activity GO:0017112
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
5 Q9UJ41 (/IDA) Q9UJ41 (/IDA) Q9UJ41 (/IDA) Q9UJ41 (/IDA) Q9W0H9 (/IDA)
Rab guanyl-nucleotide exchange factor activity GO:0017112
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
4 Q9UJ41 (/IMP) Q9UJ41 (/IMP) Q9UJ41 (/IMP) Q9UJ41 (/IMP)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
4 Q9UJ41 (/IPI) Q9UJ41 (/IPI) Q9UJ41 (/IPI) Q9UJ41 (/IPI)
Rab guanyl-nucleotide exchange factor activity GO:0017112
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q9W0H9 (/ISM)
Rab guanyl-nucleotide exchange factor activity GO:0017112
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q9JM13 (/ISO)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 Q9JM13 (/ISO)
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
1 Q9JM13 (/IDA)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
4 Q9UJ41 (/IMP) Q9UJ41 (/IMP) Q9UJ41 (/IMP) Q9UJ41 (/IMP)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 Q9JM13 (/IMP)
Negative regulation of leukocyte migration GO:0002686
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.
1 Q9JM13 (/IMP)
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
1 Q9JM13 (/ISO)
Imaginal disc-derived wing vein specification GO:0007474
The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
1 Q9W0H9 (/IMP)
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 Q9W0H9 (/IDA)
Regulation of Rab protein signal transduction GO:0032483
Any process that modulates the frequency, rate or extent of Rab protein signal transduction.
1 Q9W0H9 (/IDA)
Regulation of Rab protein signal transduction GO:0032483
Any process that modulates the frequency, rate or extent of Rab protein signal transduction.
1 Q9W0H9 (/ISM)
Negative regulation of mast cell activation GO:0033004
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.
1 Q9JM13 (/IMP)
Eye-antennal disc development GO:0035214
Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps.
1 Q9W0H9 (/IMP)
Negative regulation of multicellular organism growth GO:0040015
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.
1 Q9W0H9 (/IMP)
Negative regulation of mast cell degranulation GO:0043305
Any process that stops, prevents, or reduces the rate of mast cell degranulation.
1 Q9JM13 (/IMP)
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
1 Q9JM13 (/IMP)
Negative regulation of receptor-mediated endocytosis GO:0048261
Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
1 Q9JM13 (/IMP)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
1 Q9JM13 (/IMP)
Regulation of endosome size GO:0051036
Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis.
1 Q9W0H9 (/IGI)
Regulation of endosome size GO:0051036
Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis.
1 Q9W0H9 (/IMP)
Regulation of Fc receptor mediated stimulatory signaling pathway GO:0060368
Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
1 Q9JM13 (/IDA)
Regulation of Fc receptor mediated stimulatory signaling pathway GO:0060368
Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
1 Q9JM13 (/IMP)
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
1 Q9JM13 (/IMP)
Negative regulation of Kit signaling pathway GO:1900235
Any process that stops, prevents or reduces the frequency, rate or extent of Kit signaling pathway.
1 Q9JM13 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
9 A0A024RDL6 (/IDA) A0A024RDL6 (/IDA) A0A024RDL6 (/IDA) A0A024RDL6 (/IDA) E9PFK9 (/IDA) Q9UJ41 (/IDA) Q9UJ41 (/IDA) Q9UJ41 (/IDA) Q9UJ41 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 A0A024RDL6 (/IDA) A0A024RDL6 (/IDA) A0A024RDL6 (/IDA) A0A024RDL6 (/IDA) E9PFK9 (/IDA) Q9UJ41 (/IDA) Q9UJ41 (/IDA) Q9UJ41 (/IDA) Q9UJ41 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
4 Q9UJ41 (/IMP) Q9UJ41 (/IMP) Q9UJ41 (/IMP) Q9UJ41 (/IMP)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q9UJ41 (/TAS) Q9UJ41 (/TAS) Q9UJ41 (/TAS) Q9UJ41 (/TAS)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
4 Q9UJ41 (/TAS) Q9UJ41 (/TAS) Q9UJ41 (/TAS) Q9UJ41 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9JM13 (/ISO)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q9JM13 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9JM13 (/ISO)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
1 Q9W0H9 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 Q9JM13 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q9W0H9 (/IDA)
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