The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 20: Glutathione S-transferase P 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
11 P04906 (/IDA) P04906 (/IDA) P09211 (/IDA) P09211 (/IDA) P10299 (/IDA) P19157 (/IDA) P46425 (/IDA) Q50LC6 (/IDA) Q8JFZ2 (/IDA) Q9DDU5 (/IDA)
(1 more)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
6 Q28514 (/ISS) Q28514 (/ISS) Q28514 (/ISS) Q28514 (/ISS) Q60550 (/ISS) Q60550 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 C7DJS2 (/IPI) P09211 (/IPI) P09211 (/IPI) P10299 (/IPI) P19157 (/IPI) P91505 (/IPI)
JUN kinase binding GO:0008432
Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Kinase regulator activity GO:0019207
Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
2 P19157 (/ISO) P46425 (/ISO)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
2 P09211 (/IDA) P09211 (/IDA)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
2 P19157 (/ISO) P46425 (/ISO)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
2 P04906 (/IDA) P04906 (/IDA)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
2 P19157 (/ISO) P46425 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P04906 (/IPI) P04906 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P19157 (/ISO) P46425 (/ISO)
S-nitrosoglutathione binding GO:0035730
Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems.
2 P09211 (/IDA) P09211 (/IDA)
S-nitrosoglutathione binding GO:0035730
Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems.
2 P19157 (/ISO) P46425 (/ISO)
Dinitrosyl-iron complex binding GO:0035731
Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO.
2 P09211 (/IDA) P09211 (/IDA)
Dinitrosyl-iron complex binding GO:0035731
Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO.
2 P19157 (/ISO) P46425 (/ISO)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
2 P04906 (/IDA) P04906 (/IDA)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
2 P19157 (/ISO) P46425 (/ISO)
Nitric oxide binding GO:0070026
Interacting selectively and non-covalently with nitric oxide (NO).
2 P09211 (/NAS) P09211 (/NAS)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
1 Q9N4X8 (/IMP)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
1 Q9N4X8 (/TAS)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 P19157 (/ISS)
JUN kinase binding GO:0008432
Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
1 P19157 (/IPI)
Kinase regulator activity GO:0019207
Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 P19157 (/IMP)

There are 99 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
7 P19157 (/ISS) Q28514 (/ISS) Q28514 (/ISS) Q28514 (/ISS) Q28514 (/ISS) Q60550 (/ISS) Q60550 (/ISS)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
6 P09211 (/IDA) P09211 (/IDA) P19157 (/IDA) P46425 (/IDA) Q8JFZ2 (/IDA) Q9N4X8 (/IDA)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
6 Q28514 (/ISS) Q28514 (/ISS) Q28514 (/ISS) Q28514 (/ISS) Q60550 (/ISS) Q60550 (/ISS)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
4 P04906 (/IDA) P04906 (/IDA) P09211 (/IDA) P09211 (/IDA)
Regulation of stress-activated MAPK cascade GO:0032872
Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Negative regulation of stress-activated MAPK cascade GO:0032873
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Common myeloid progenitor cell proliferation GO:0035726
The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Negative regulation of leukocyte proliferation GO:0070664
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
4 P04906 (/ISS) P04906 (/ISS) P09211 (/ISS) P09211 (/ISS)
Negative regulation of acute inflammatory response GO:0002674
Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.
3 P09211 (/NAS) P09211 (/NAS) P19157 (/NAS)
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
3 P09211 (/IDA) P09211 (/IDA) P19157 (/IDA)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
3 P09211 (/IDA) P09211 (/IDA) P19157 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 P09211 (/TAS) P09211 (/TAS) P19157 (/TAS)
Negative regulation of JUN kinase activity GO:0043508
Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
3 P09211 (/IDA) P09211 (/IDA) P19157 (/IDA)
Negative regulation of nitric-oxide synthase biosynthetic process GO:0051771
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.
3 P09211 (/IDA) P09211 (/IDA) P19157 (/IDA)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 P09211 (/IDA) P09211 (/IDA) P19157 (/IDA)
Negative regulation of monocyte chemotactic protein-1 production GO:0071638
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1.
3 P09211 (/IDA) P09211 (/IDA) P19157 (/IDA)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
2 P09211 (/IDA) P09211 (/IDA)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
2 P04906 (/IMP) P04906 (/IMP)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
2 P04906 (/TAS) P04906 (/TAS)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2 P09211 (/TAS) P09211 (/TAS)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
2 P04906 (/IEP) P04906 (/IEP)
Negative regulation of biosynthetic process GO:0009890
Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
2 P09211 (/IDA) P09211 (/IDA)
Negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804
Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2 P09211 (/IC) P09211 (/IC)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
2 P04906 (/IEP) P04906 (/IEP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
2 P04906 (/IEP) P04906 (/IEP)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
2 P04906 (/IEP) P04906 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
2 P04906 (/IEP) P04906 (/IEP)
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
2 P04906 (/ISS) P04906 (/ISS)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
2 P04906 (/ISS) P04906 (/ISS)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 P04906 (/IEP) P04906 (/IEP)
Response to L-ascorbic acid GO:0033591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus.
2 P04906 (/IEP) P04906 (/IEP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 P09211 (/TAS) P09211 (/TAS)
Nitric oxide storage GO:0035732
The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins.
2 P09211 (/NAS) P09211 (/NAS)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
2 P04906 (/IEP) P04906 (/IEP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P09211 (/TAS) P09211 (/TAS)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
2 P09211 (/IDA) P09211 (/IDA)
Negative regulation of MAPK cascade GO:0043409
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
2 P09211 (/NAS) P09211 (/NAS)
Negative regulation of JUN kinase activity GO:0043508
Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
2 P04906 (/ISS) P04906 (/ISS)
Linoleic acid metabolic process GO:0043651
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
2 P09211 (/IDA) P09211 (/IDA)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
2 P04906 (/IEP) P04906 (/IEP)
Negative regulation of nitric-oxide synthase biosynthetic process GO:0051771
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.
2 P04906 (/ISS) P04906 (/ISS)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P04906 (/ISS) P04906 (/ISS)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
2 P04906 (/IEP) P04906 (/IEP)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
2 P04906 (/IEP) P04906 (/IEP)
Cellular response to cell-matrix adhesion GO:0071460
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion.
2 P04906 (/IEP) P04906 (/IEP)
Negative regulation of monocyte chemotactic protein-1 production GO:0071638
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1.
2 P04906 (/ISS) P04906 (/ISS)
Negative regulation of smooth muscle cell chemotaxis GO:0071672
Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis.
2 P04906 (/IMP) P04906 (/IMP)
Glutathione derivative biosynthetic process GO:1901687
The chemical reactions and pathways resulting in the formation of glutathione derivative.
2 P09211 (/TAS) P09211 (/TAS)
Negative regulation of vascular smooth muscle cell proliferation GO:1904706
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.
2 P04906 (/IMP) P04906 (/IMP)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
2 P09211 (/IDA) P09211 (/IDA)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 P19157 (/IDA)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
1 Q9N4X8 (/TAS)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q9N4X8 (/IMP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 Q50LC6 (/IMP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 P19157 (/ISS)
Response to UV-C GO:0010225
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm.
1 Q9N4X8 (/IMP)
Heat acclimation GO:0010286
Any process that increases heat tolerance of an organism in response to high temperatures.
1 Q9N4X8 (/IMP)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
1 P19157 (/ISS)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 P19157 (/ISS)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 P19157 (/ISS)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P19157 (/ISS)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P19157 (/ISS)
Regulation of stress-activated MAPK cascade GO:0032872
Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
1 P19157 (/IDA)
Negative regulation of stress-activated MAPK cascade GO:0032873
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
1 P19157 (/IDA)
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
1 P19157 (/IMP)
Response to L-ascorbic acid GO:0033591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus.
1 P19157 (/ISS)
Common myeloid progenitor cell proliferation GO:0035726
The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.
1 P19157 (/IMP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q9N4X8 (/IMP)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
1 P19157 (/IDA)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
1 P19157 (/ISS)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
1 P19157 (/ISS)
Negative regulation of JUN kinase activity GO:0043508
Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
1 P19157 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 P10299 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P19157 (/ISS)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 P19157 (/IMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 P10299 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q9N4X8 (/IMP)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P19157 (/IDA)
Negative regulation of leukocyte proliferation GO:0070664
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.
1 P19157 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P19157 (/IDA)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 P19157 (/ISS)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P19157 (/ISS)
Cellular response to cell-matrix adhesion GO:0071460
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion.
1 P19157 (/ISS)
Cellular response to xenobiotic stimulus GO:0071466
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
1 Q9DDU5 (/IDA)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P10299 (/IGI)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P10299 (/IMP)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 P10299 (/IGI)
Negative regulation of cellular response to manganese ion GO:1905803
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to manganese ion.
1 P10299 (/IGI)
Positive regulation of cellular response to manganese ion GO:1905804
Any process that activates or increases the frequency, rate or extent of cellular response to manganese ion.
1 P10299 (/IGI)
Positive regulation of cellular response to manganese ion GO:1905804
Any process that activates or increases the frequency, rate or extent of cellular response to manganese ion.
1 P10299 (/IMP)
Negative regulation of neutrophil aggregation GO:2000429
Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil aggregation.
1 P19157 (/NAS)
Negative regulation of peroxidase activity GO:2000469
Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity.
1 P19157 (/IDA)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 P19157 (/ISS)

There are 34 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P04906 (/IDA) P04906 (/IDA) P09211 (/IDA) P09211 (/IDA) V9HWE9 (/IDA) V9HWE9 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
5 A0A060X8J1 (/ISS) B5XBZ2 (/ISS) B5XGZ2 (/ISS) L7QI61 (/ISS) Q9W647 (/ISS)
Sensory dendrite GO:0071683
A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron.
5 A0A060X8J1 (/ISS) B5XBZ2 (/ISS) B5XGZ2 (/ISS) L7QI61 (/ISS) Q9W647 (/ISS)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
5 A0A060X8J1 (/ISS) B5XBZ2 (/ISS) B5XGZ2 (/ISS) L7QI61 (/ISS) Q9W647 (/ISS)
Dendritic knob GO:0098788
The terminal swelling of an apical dendrite of a ciliated olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium.
5 A0A060X8J1 (/ISS) B5XBZ2 (/ISS) B5XGZ2 (/ISS) L7QI61 (/ISS) Q9W647 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P09211 (/IDA) P09211 (/IDA) V9HWE9 (/IDA) V9HWE9 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P09211 (/TAS) P09211 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P09211 (/HDA) P09211 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P04906 (/IDA) P04906 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P19157 (/ISO) P46425 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P04906 (/IDA) P04906 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P19157 (/ISO) P46425 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P09211 (/TAS) P09211 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P19157 (/ISO) P46425 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P19157 (/ISO) P46425 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P09211 (/TAS) P09211 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P04906 (/IDA) P04906 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P19157 (/ISO) P46425 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
2 P09211 (/HDA) P09211 (/HDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P04906 (/ISS) P04906 (/ISS)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
2 P09211 (/TAS) P09211 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P09211 (/HDA) P09211 (/HDA)
TRAF2-GSTP1 complex GO:0097057
A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses.
2 P09211 (/IDA) P09211 (/IDA)
TRAF2-GSTP1 complex GO:0097057
A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses.
2 P19157 (/ISO) P46425 (/ISO)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
2 P09211 (/TAS) P09211 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P19157 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P19157 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P19157 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P19157 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P19157 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 A0A060WT29 (/IDA)
Sensory dendrite GO:0071683
A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron.
1 A0A060WT29 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 A0A060WT29 (/IDA)
Dendritic knob GO:0098788
The terminal swelling of an apical dendrite of a ciliated olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium.
1 A0A060WT29 (/IDA)
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