The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Region D6 of dynein motor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Dynein heavy chain 9, axonemal

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ATP-dependent microtubule motor activity, minus-end-directed GO:0008569
Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP.
3 A0A0B4KHJ4 (/ISS) Q0KI05 (/ISS) Q9VDG0 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q69Z23 (/IPI) Q9NYC9 (/IPI)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 Q386I6 (/ISM)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 Q9UFH2 (/NAS)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Epithelial cilium movement involved in extracellular fluid movement GO:0003351
The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
5 A0A2R8QP75 (/IMP) A0A2R8RQB1 (/IMP) E9Q7N9 (/IMP) I3ITD2 (/IMP) Q9QZH1 (/IMP)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
3 E9Q7N9 (/IMP) Q9NYC9 (/IMP) Q9QZH1 (/IMP)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
3 A0A0B4KHJ4 (/ISS) Q0KI05 (/ISS) Q9VDG0 (/ISS)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
3 E9Q7N9 (/IMP) Q96DT5 (/IMP) Q9QZH1 (/IMP)
Cardiac septum development GO:0003279
The progression of a cardiac septum over time, from its initial formation to the mature structure.
2 E9Q7N9 (/IMP) Q9QZH1 (/IMP)
Regulation of cilium beat frequency GO:0003356
Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium.
2 E9Q7N9 (/ISO) Q9QZH1 (/ISO)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
2 E9Q7N9 (/ISO) Q9QZH1 (/ISO)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 E9Q7N9 (/IMP) Q9QZH1 (/IMP)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
2 A0A0B4KHJ4 (/IMP) Q9VDG0 (/IMP)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
2 E9Q7N9 (/IMP) Q9QZH1 (/IMP)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
2 E9Q7N9 (/ISO) Q9QZH1 (/ISO)
Determination of left/right asymmetry in nervous system GO:0035545
The establishment of the nervous system with respect to the left and right halves.
2 E9Q7N9 (/IMP) Q9QZH1 (/IMP)
Epithelial cilium movement involved in determination of left/right asymmetry GO:0060287
The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves.
2 E9Q7N9 (/IMP) Q9QZH1 (/IMP)
Cardiac septum morphogenesis GO:0060411
The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.
2 E9Q7N9 (/IMP) Q9QZH1 (/IMP)
Determination of heart left/right asymmetry GO:0061371
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
2 E9Q7N9 (/IMP) Q9QZH1 (/IMP)
Sperm flagellum movement involved in flagellated sperm motility GO:1905419
The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
2 E9Q7N9 (/IMP) Q9QZH1 (/IMP)
Regulation of cilium beat frequency GO:0003356
Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium.
1 Q96DT5 (/IMP)
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
1 Q386I6 (/ISM)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 Q96DT5 (/IMP)
Cilium-dependent cell motility GO:0060285
Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 Q9UFH2 (/NAS)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
4 E9Q7N9 (/IDA) Q386I6 (/IDA) Q9NYC9 (/IDA) Q9QZH1 (/IDA)
9+2 motile cilium GO:0097729
A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
4 E9Q7N9 (/IDA) Q96DT5 (/IDA) Q9NYC9 (/IDA) Q9QZH1 (/IDA)
9+2 motile cilium GO:0097729
A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
4 B1AR51 (/ISO) E9Q7N9 (/ISO) F7DC70 (/ISO) Q9QZH1 (/ISO)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
3 B1AR51 (/ISO) F7DC70 (/ISO) Q4QFY9 (/ISO)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
3 A0A0B4KHJ4 (/ISS) Q0KI05 (/ISS) Q9VDG0 (/ISS)
Proximal portion of axoneme GO:0120134
The portion of the axoneme that is close to the base of the cilium.
3 E9Q7N9 (/IDA) Q96DT5 (/IDA) Q9QZH1 (/IDA)
Axonemal dynein complex GO:0005858
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
2 Q5LJN5 (/IMP) Q9U3Y5 (/IMP)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
2 E9Q7N9 (/IMP) Q9QZH1 (/IMP)
9+0 motile cilium GO:0097728
A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme).
2 E9Q7N9 (/IDA) Q9QZH1 (/IDA)
Proximal portion of axoneme GO:0120134
The portion of the axoneme that is close to the base of the cilium.
2 E9Q7N9 (/ISO) Q9QZH1 (/ISO)
Distal portion of axoneme GO:0120135
The portion of the axoneme that is close to the tip of the cilium.
2 B1AR51 (/ISO) F7DC70 (/ISO)
Axonemal dynein complex GO:0005858
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
1 Q9UFH2 (/NAS)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 Q386I6 (/IDA)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
1 Q386I6 (/ISM)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 Q69Z23 (/ISM)
Distal portion of axoneme GO:0120135
The portion of the axoneme that is close to the tip of the cilium.
1 Q9NYC9 (/IDA)
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