The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PDCD5-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Programmed cell death protein 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI)
(3 more)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
13 O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA)
(3 more)
Acetyltransferase activator activity GO:0010698
Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule.
13 O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA)
(3 more)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
13 O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI) O14737 (/IPI)
(3 more)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2 P56812 (/ISO) P56812 (/ISO)
Acetyltransferase activator activity GO:0010698
Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule.
2 P56812 (/ISO) P56812 (/ISO)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
2 P56812 (/ISO) P56812 (/ISO)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
13 O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP)
(3 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
13 O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA)
(3 more)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
13 O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP)
(3 more)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
13 O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP)
(3 more)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
13 O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA)
(3 more)
Positive regulation of release of cytochrome c from mitochondria GO:0090200
Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
13 O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP)
(3 more)
Positive regulation of protein import into mitochondrial outer membrane GO:1903638
Any process that activates or increases the frequency, rate or extent of protein import into mitochondrial outer membrane.
13 O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP)
(3 more)
Negative regulation of chaperone-mediated protein folding GO:1903645
Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding.
13 O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP) O14737 (/IMP)
(3 more)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
2 P56812 (/ISO) P56812 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 P56812 (/ISO) P56812 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P56812 (/ISO) P56812 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 P56812 (/ISO) P56812 (/ISO)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
2 P56812 (/ISO) P56812 (/ISO)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
2 P56812 (/ISO) P56812 (/ISO)
Positive regulation of release of cytochrome c from mitochondria GO:0090200
Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2 P56812 (/ISO) P56812 (/ISO)
Positive regulation of protein import into mitochondrial outer membrane GO:1903638
Any process that activates or increases the frequency, rate or extent of protein import into mitochondrial outer membrane.
2 P56812 (/ISO) P56812 (/ISO)
Negative regulation of chaperone-mediated protein folding GO:1903645
Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding.
2 P56812 (/ISO) P56812 (/ISO)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
13 O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA) O14737 (/IDA)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA)
(3 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
13 O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA) O14737 (/HDA)
(3 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P56812 (/ISO) P56812 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P56812 (/ISO) P56812 (/ISO)