The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"DNA helicase RuvA subunit, C-terminal domain
".
FunFam 142: Tyrosyl-DNA phosphodiesterase 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
4 | A5D8M0 (/ISS) F1NW29 (/ISS) Q28FQ5 (/ISS) Q5XJA0 (/ISS) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
4 | A5D8M0 (/ISS) F1NW29 (/ISS) Q28FQ5 (/ISS) Q5XJA0 (/ISS) |
|
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
|
4 | A5D8M0 (/ISS) F1NW29 (/ISS) Q28FQ5 (/ISS) Q5XJA0 (/ISS) |
|
5'-tyrosyl-DNA phosphodiesterase activity GO:0070260
Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA.
|
4 | A5D8M0 (/ISS) F1NW29 (/ISS) Q28FQ5 (/ISS) Q5XJA0 (/ISS) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q5XJA0 (/IDA) |
|
Tyrosyl-DNA phosphodiesterase activity GO:0070259
Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA.
|
1 | Q5XJA0 (/IDA) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
4 | A5D8M0 (/ISS) F1NW29 (/ISS) Q28FQ5 (/ISS) Q5XJA0 (/ISS) |
|
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
|
1 | Q5XJA0 (/IMP) |
|
Gastrulation GO:0007369
A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
|
1 | Q5XJA0 (/IMP) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
1 | Q5XJA0 (/IMP) |
|
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
|
1 | Q5XJA0 (/IMP) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
3 | A5D8M0 (/ISS) Q28FQ5 (/ISS) Q5XJA0 (/ISS) |
