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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 58: Fatty acid oxygenase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
9,12-octadecadienoate 8-hydroperoxide 8R-isomerase. [EC: 5.4.4.5]
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8- dihydroxyoctadeca-9,12-dienoate.
  • The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyze two separate reactions.
  • Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60), which is subsequently isomerized to (5S,8R,9Z,12Z)- 5,8-dihydroxyoctadeca-9,12-dienoate within the C-terminal P450 heme thiolate domain.
 6 B0Y6R2 G5EB19 G5EB19 Q4WPX2 Q6RET3 Q6RET3
Linoleate 8R-lipoxygenase. [EC: 1.13.11.60]
Linoleate + O(2) = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate.
  • The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyze two separate reactions.
  • Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, which is subsequently isomerized by the C-terminal P450 heme thiolate domain to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.5).
  • The bifunctional enzyme from Gaeumannomyces graminis also catalyzes the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca- 9,12-dienoate, but its second domain isomerizes it to (7S,8S,9Z,12Z)- 5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.6).
  • Formerly EC 1.13.11.44.
 6 B0Y6R2 G5EB19 G5EB19 Q4WPX2 Q6RET3 Q6RET3
Linoleate 10R-lipoxygenase. [EC: 1.13.11.62]
Linoleate + O(2) = (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate.
  • The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp.
 1 Q4WY82