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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 49: steroid 21-hydroxylase isoform X1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Steroid 21-monooxygenase. [EC: 1.14.14.16]
A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • For the conversion of progesterone and 17-alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol.
  • Involved in the biosynthesis of the hormones aldosterone and cortisol.
  • The electron donor is EC 1.6.2.4.
  • Formerly EC 1.14.1.8, EC 1.14.99.10 and EC 1.99.1.11.
 14 K9LHU1 K9LHU1 P00191 P03940 P08686 P08686 P15540 Q2LA59 Q2LA60 Q2LCM1
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