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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Cytochrome P450

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Unspecific monooxygenase. [EC: 1.14.14.1]
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
  • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
  • Some of the reactions attributed to EC 1.14.15.3 belong here.
  • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
 7 A0A178WHA9 A0A178WHA9 O23066 O80823 Q9CAD6 Q9LMM1 Q9LMM1
Jasmonoyl-L-amino acid 12-hydroxylase. [EC: 1.14.14.48]
A jasmonoyl-L-amino acid + [reduced NADPH--hemoprotein reductase] + O(2) = a 12-hydroxyjasmonoyl-L-amino acid + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • The enzyme, found in plants, acts on jasmonoyl-L-amino conjugates, catalyzing the hydroxylation of the C-12 position of the jasmonic acid chain.
  • While the best studied substrate is (+)-7-epi-jasmonoyl-L-isoleucine, the enzyme was shown to be active with jasmonoyl-L-valine and jasmonoyl-L-phenylalanine, and is likely to be active with other jasmonoyl-amino acid conjugates.
 5 A0A178V8H3 A0A178V8H3 Q9FMV7 Q9SMP5 Q9SMP5
12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase. [EC: 1.14.14.49]
A 12-hydroxyjasmonoyl-L-amino acid + 2 [reduced NADPH--hemoprotein reductase] + 2 O(2) = a 12-hydroxy-12-oxojasmonoyl-L-amino acid + 2 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O.
  • The enzyme, found in plants, acts on jasmonoyl-L-amino conjugates that have been hydroxylated at the C-12 position of the jasmonic acid chain by EC 1.14.14.48 further oxidizing that position to a carboxylate via an aldehyde intermediate.
  • While the best studied substrate is (+)-7-iso-jasmonoyl-L-isoleucine, the enzyme was shown to be active with jasmonoyl-L-phenylalanine, and is likely to be active with other jasmonoyl-amino acid conjugates.
 1 Q9ZUX1
Long-chain fatty acid omega-monooxygenase. [EC: 1.14.14.80]
A long-chain fatty acid + [reduced NADPH--hemoprotein reductase] + O(2) = an omega-hydroxy-long-chain fatty acid + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme thiolate) enzyme.
  • The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1).
  • The plant enzyme CYP86A1 also acts on laurate (12:0).
  • The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C(16) to C(20) saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position.
  • The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4).
  • Formerly EC 1.14.13.205.
 1 P48422
Long-chain acyl-CoA omega-monooxygenase. [EC: 1.14.14.129]
(1) Oleoyl-CoA + [reduced NADPH--hemoprotein reductase] + O(2) = 18-hydroxyoleoyl-CoA + [oxidized NADPH--hemoprotein reductase] + H(2)O. (2) Linoleoyl-CoA + [reduced NADPH--hemoprotein reductase] + O(2) = 18-hydroxylinoleoyl-CoA + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein.
  • The enzymes from solanaceous plants are involved in the biosynthesis of stigmatic estolide, a lipid-based polyester that forms a major component of the exudate.
  • Formerly EC 1.14.13.204.
 1 B3RFJ6
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