The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cytochrome P450
".
FunFam 34: Cholesterol 7-alpha-monooxygenase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cholesterol 7-alpha-monooxygenase activity GO:0008123
Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O.
|
8 | O46491 (/ISS) O46491 (/ISS) O46491 (/ISS) P22680 (/ISS) P46634 (/ISS) P46634 (/ISS) P51542 (/ISS) Q64505 (/ISS) |
|
Cholesterol 7-alpha-monooxygenase activity GO:0008123
Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O.
|
3 | P18125 (/IDA) P22680 (/IDA) Q64505 (/IDA) |
|
Cholesterol 7-alpha-monooxygenase activity GO:0008123
Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O.
|
1 | Q64505 (/ISO) |
There are 26 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
|
8 | O46491 (/ISS) O46491 (/ISS) O46491 (/ISS) P22680 (/ISS) P46634 (/ISS) P46634 (/ISS) P51542 (/ISS) Q64505 (/ISS) |
|
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
8 | O46491 (/ISS) O46491 (/ISS) O46491 (/ISS) P22680 (/ISS) P46634 (/ISS) P46634 (/ISS) P51542 (/ISS) Q64505 (/ISS) |
|
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
8 | O46491 (/ISS) O46491 (/ISS) O46491 (/ISS) P22680 (/ISS) P46634 (/ISS) P46634 (/ISS) P51542 (/ISS) Q64505 (/ISS) |
|
Regulation of bile acid biosynthetic process GO:0070857
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
|
8 | O46491 (/ISS) O46491 (/ISS) O46491 (/ISS) P22680 (/ISS) P46634 (/ISS) P46634 (/ISS) P51542 (/ISS) Q64505 (/ISS) |
|
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
8 | O46491 (/ISS) O46491 (/ISS) O46491 (/ISS) P18125 (/ISS) P46634 (/ISS) P46634 (/ISS) P51542 (/ISS) Q64505 (/ISS) |
|
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
|
8 | O46491 (/ISS) O46491 (/ISS) O46491 (/ISS) P22680 (/ISS) P46634 (/ISS) P46634 (/ISS) P51542 (/ISS) Q64505 (/ISS) |
|
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
|
2 | P18125 (/IDA) P22680 (/IDA) |
|
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
|
2 | P18125 (/TAS) P22680 (/TAS) |
|
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
2 | P18125 (/IDA) Q64505 (/IDA) |
|
Regulation of bile acid biosynthetic process GO:0070857
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
|
2 | P18125 (/IDA) P22680 (/IDA) |
|
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
|
1 | Q64505 (/ISO) |
|
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | Q64505 (/ISO) |
|
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
1 | P22680 (/TAS) |
|
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
1 | P22680 (/TAS) |
|
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
1 | P18125 (/IDA) |
|
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
1 | Q64505 (/ISO) |
|
Positive regulation of cholesterol biosynthetic process GO:0045542
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
|
1 | P18125 (/IDA) |
|
Positive regulation of cholesterol biosynthetic process GO:0045542
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
|
1 | Q64505 (/ISO) |
|
Negative regulation of fatty acid biosynthetic process GO:0045717
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
|
1 | P18125 (/IDA) |
|
Negative regulation of fatty acid biosynthetic process GO:0045717
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
|
1 | Q64505 (/ISO) |
|
Regulation of bile acid biosynthetic process GO:0070857
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
|
1 | Q64505 (/ISO) |
|
Positive regulation of bile acid biosynthetic process GO:0070859
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
|
1 | Q64505 (/TAS) |
|
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
1 | P22680 (/IDA) |
|
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
1 | Q64505 (/ISO) |
|
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
|
1 | P18125 (/IDA) |
|
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
|
1 | Q64505 (/ISO) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
8 | O46491 (/ISS) O46491 (/ISS) O46491 (/ISS) P22680 (/ISS) P46634 (/ISS) P46634 (/ISS) P51542 (/ISS) Q64505 (/ISS) |
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
1 | P22680 (/TAS) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | P18125 (/IDA) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | Q64505 (/ISO) |
