The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29: Cytochrome P450 734A1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
11-oxo-beta-amyrin 30-oxidase. [EC: 1.14.14.115]
11-oxo-beta-amyrin + 3 O(2) + 3 [reduced NADPH--hemoprotein reductase] = glycyrrhetinate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O.
  • A cytochrome P450 (heme-thiolate) protein.
  • The enzyme from the plant Glycyrrhiza uralensis (licorice) is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin.
  • The enzyme from the plant Medicago truncatula can also hydroxylate beta-amyrin.
  • Formerly EC 1.14.13.173.
2 H1A981 H1A988
Secologanin synthase. [EC: 1.14.19.62]
Loganin + [reduced NADPH--hemoprotein reductase] + O(2) = secologanin + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O.
  • A cytochrome P450 (heme-thiolate) protein.
  • Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids.
  • Formerly EC 1.3.3.9.
2 Q05047 U5NDT8
7-deoxyloganate 7-hydroxylase. [EC: 1.14.14.85]
7-deoxyloganate + [reduced NADPH--hemoprotein reductase] + O(2) = loganate + [oxidized NADPH--hemoprotein reductase] + H(2)O.
    1 U5NE19
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