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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 271: Cytochrome P450 monooxygenase PikC

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pikromycin synthase. [EC: 1.14.15.33]
(1) Narbomycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = pikromycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. (2) Narbomycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = neopikromycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. (3) Narbomycin + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H(+) + 2 O(2) = novapikromyin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O. (4) 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. (5) 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = neomethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. (6) 10-deoxymethymycin + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H(+) + 2 O(2) = novamethymycin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O.
  • A cytochrome P450 (heme-thiolate) protein.
  • Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit.
  • With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin.
  • With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin.
  • Formerly EC 1.14.13.185.
 4 A0A0S2HKV8 A0A0S2HKV8 O87605 O87605
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