The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 25: Prostaglandin I2 (prostacyclin) synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Prostaglandin-I synthase activity GO:0008116
Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).
17 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(7 more)
Prostaglandin-I synthase activity GO:0008116
Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).
3 F1RE08 (/IDA) Q16647 (/IDA) Q62969 (/IDA)
Sterol 12-alpha-hydroxylase activity GO:0008397
Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.
2 G3V8J2 (/IDA) Q9WVT5 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
2 F1RE08 (/IDA) Q16647 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q16647 (/IPI)
Prostaglandin-I synthase activity GO:0008116
Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).
1 Q62969 (/IMP)
Prostaglandin-I synthase activity GO:0008116
Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).
1 O35074 (/ISO)
Sterol 12-alpha-hydroxylase activity GO:0008397
Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.
1 O88962 (/ISO)
Sterol 12-alpha-hydroxylase activity GO:0008397
Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.
1 Q9UNU6 (/TAS)
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
1 Q9UNU6 (/TAS)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 O35074 (/ISO)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Prostaglandin biosynthetic process GO:0001516
The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Positive regulation of peroxisome proliferator activated receptor signaling pathway GO:0035360
Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Positive regulation of execution phase of apoptosis GO:1900119
Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Prostaglandin biosynthetic process GO:0001516
The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
3 F1RE08 (/IDA) Q16647 (/IDA) Q62969 (/IDA)
Prostaglandin biosynthetic process GO:0001516
The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
1 O35074 (/ISO)
Prostaglandin biosynthetic process GO:0001516
The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
1 Q62969 (/TAS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q62969 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 O35074 (/ISO)
Icosanoid metabolic process GO:0006690
The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.
1 Q16647 (/TAS)
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
1 Q9UNU6 (/TAS)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
1 O35074 (/IDA)
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 Q9UNU6 (/TAS)
Cyclooxygenase pathway GO:0019371
The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.
1 Q16647 (/TAS)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 Q16647 (/IDA)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 O35074 (/ISO)
NAD biosynthesis via nicotinamide riboside salvage pathway GO:0034356
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside.
1 Q16647 (/TAS)
Positive regulation of peroxisome proliferator activated receptor signaling pathway GO:0035360
Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.
1 Q16647 (/IDA)
Positive regulation of peroxisome proliferator activated receptor signaling pathway GO:0035360
Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.
1 O35074 (/ISO)
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q16647 (/IDA)
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 O35074 (/ISO)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 Q16647 (/IMP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 O35074 (/ISO)
Decidualization GO:0046697
The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
1 O35074 (/IDA)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
1 Q16647 (/IDA)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
1 O35074 (/ISO)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q16647 (/IEP)
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
1 Q16647 (/IEP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q16647 (/IDA)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 O35074 (/ISO)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 Q16647 (/IDA)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 O35074 (/ISO)
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
1 F1SBE5 (/IMP)
Positive regulation of execution phase of apoptosis GO:1900119
Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.
1 Q16647 (/IDA)
Positive regulation of execution phase of apoptosis GO:1900119
Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.
1 O35074 (/ISO)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
18 D2GVP2 (/ISS) F1PZ83 (/ISS) F1SBE5 (/ISS) F6YMG4 (/ISS) F7ATG7 (/ISS) F7F0C0 (/ISS) F7F0C0 (/ISS) G1NZM3 (/ISS) G1R5M7 (/ISS) G3HET1 (/ISS)
(8 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O35074 (/IDA) Q16647 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 Q16647 (/TAS) Q9UNU6 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q62969 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 O35074 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O35074 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O35074 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q16647 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 O35074 (/ISO)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 Q16647 (/IDA)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 O35074 (/ISO)
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