The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cytochrome P450
".
FunFam 18: Cytochrome P450 monooxygenase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
16 |
D5E3H2 (/IDA)
E3VWI3 (/IDA)
E3VWJ9 (/IDA)
P18326 (/IDA)
P9WPL5 (/IDA)
P9WPL5 (/IDA)
P9WPL5 (/IDA)
P9WPL5 (/IDA)
P9WPL5 (/IDA)
Q00441 (/IDA)
(6 more) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
10 | D5E3H2 (/IDA) E3VWI3 (/IDA) E3VWJ9 (/IDA) Q00441 (/IDA) Q00441 (/IDA) Q59523 (/IDA) Q9FCA6 (/IDA) Q9FCA6 (/IDA) Q9FCA6 (/IDA) Q9KZF5 (/IDA) |
|
Monooxygenase activity GO:0004497
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
|
9 | D5E3H2 (/IDA) Q00441 (/IDA) Q00441 (/IDA) Q59523 (/IDA) Q83WF5 (/IDA) Q9FCA6 (/IDA) Q9FCA6 (/IDA) Q9FCA6 (/IDA) Q9KZF5 (/IDA) |
|
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
|
5 | Q84HB6 (/IDA) Q9FCA6 (/IDA) Q9FCA6 (/IDA) Q9FCA6 (/IDA) Q9KZF5 (/IDA) |
|
Cholesterol 26-hydroxylase activity GO:0031073
Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol.
|
5 | P9WPL5 (/IDA) P9WPL5 (/IDA) P9WPL5 (/IDA) P9WPL5 (/IDA) P9WPL5 (/IDA) |
|
Cholest-4-en-3-one 26-monooxygenase activity GO:0036199
Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate.
|
5 | P9WPL5 (/IDA) P9WPL5 (/IDA) P9WPL5 (/IDA) P9WPL5 (/IDA) P9WPL5 (/IDA) |
|
Oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor GO:0016636
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein.
|
2 | E3VWI3 (/IDA) E3VWJ9 (/IDA) |
|
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
|
1 | Q5LX14 (/ISS) |
|
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
|
1 | Q9KIZ4 (/NAS) |
|
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.
|
1 | P18326 (/IDA) |
|
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen GO:0016713
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor.
|
1 | Q825I8 (/IDA) |
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
1 | P9WPL4 (/ISS) |
|
Cholesterol 26-hydroxylase activity GO:0031073
Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol.
|
1 | P9WPL4 (/ISS) |
|
Cholest-4-en-3-one 26-monooxygenase activity GO:0036199
Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate.
|
1 | P9WPL4 (/ISS) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
11 |
E3VWI3 (/IDA)
E3VWJ9 (/IDA)
Q00441 (/IDA)
Q00441 (/IDA)
Q59523 (/IDA)
Q825I8 (/IDA)
Q83WF5 (/IDA)
Q9FCA6 (/IDA)
Q9FCA6 (/IDA)
Q9FCA6 (/IDA)
(1 more) |
|
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
5 | P9WPL5 (/IDA) P9WPL5 (/IDA) P9WPL5 (/IDA) P9WPL5 (/IDA) P9WPL5 (/IDA) |
|
Pigment metabolic process GO:0042440
The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.
|
4 | Q9FCA6 (/IDA) Q9FCA6 (/IDA) Q9FCA6 (/IDA) Q9KZF5 (/IDA) |
|
Antibiotic biosynthetic process GO:0017000
The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
|
3 | Q59523 (/IDA) Q825I8 (/IDA) Q83WF5 (/IDA) |
|
Biotin biosynthetic process GO:0009102
The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
|
2 | P53554 (/IDA) P53554 (/IDA) |
|
Antibiotic biosynthetic process GO:0017000
The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
|
2 | Q59523 (/IMP) Q83WF5 (/IMP) |
|
Erythromycin biosynthetic process GO:1901115
The chemical reactions and pathways resulting in the formation of erythromycin.
|
2 | Q00441 (/IDA) Q00441 (/IDA) |
|
Pentalenolactone biosynthetic process GO:1901780
The chemical reactions and pathways resulting in the formation of pentalenolactone.
|
2 | E3VWI3 (/IDA) E3VWJ9 (/IDA) |
|
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | P9WPL4 (/ISS) |
|
Antibiotic metabolic process GO:0016999
The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
|
1 | Q9ZHQ1 (/IMP) |
|
Epothilone biosynthetic process GO:0050814
The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer.
|
1 | Q9KIZ4 (/IDA) |
|
Vitamin D3 metabolic process GO:0070640
The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol.
|
1 | P18326 (/IDA) |
|
Lactone biosynthetic process GO:1901336
The chemical reactions and pathways resulting in the formation of lactone.
|
1 | Q825I8 (/IDA) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | P9WPP5 (/HDA) P9WPP5 (/HDA) P9WPP5 (/HDA) P9WPP5 (/HDA) P9WPP5 (/HDA) P9WPP5 (/HDA) P9WPP5 (/HDA) |
|
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
|
5 | P9WPL5 (/HDA) P9WPL5 (/HDA) P9WPL5 (/HDA) P9WPL5 (/HDA) P9WPL5 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P18326 (/IDA) |
