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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 147: (S)-stylopine synthase 1

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
(S)-stylopine synthase. [EC: 1.14.19.64]
(S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O(2) = (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O.
  • A cytochrome P450 (heme-thiolate) protein catalyzing an oxidative reaction that does not incorporate oxygen into the product.
  • Forms the second methylenedioxy bridge of the protoberberine alkaloid stylopine from oxidative ring closure of adjacent phenolic and methoxy groups of cheilanthifoline.
  • Formerly EC 1.1.3.32 and EC 1.14.21.1.
 3 B1NF19 Q50LH3 Q50LH4
(S)-canadine synthase. [EC: 1.14.19.68]
(S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O(2) = (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O.
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • The enzyme catalyzes an oxidative reaction that does not incorporate oxygen into the product.
  • Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine.
  • Formerly EC 1.1.3.36 and EC 1.14.21.5.
 3 B1NF19 Q50LH4 Q948Y1
(S)-cheilanthifoline synthase. [EC: 1.14.19.65]
(S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O(2) = (S)- cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O.
  • A cytochrome P450 (heme-thiolate) protein catalyzing an oxidative reaction that does not incorporate oxygen into the product.
  • Forms the methylenedioxy bridge of the protoberberine alkaloid cheilanthifoline by the oxidative ring closure of adjacent phenolic and methoxy groups of scoulerine.
  • Cf. EC 1.14.19.73 which catalyzes a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-nandinine.
  • Formerly EC 1.1.3.33 and EC 1.14.21.2.
 2 B1NF20 B5UAQ8
(S)-nandinine synthase. [EC: 1.14.19.73]
(S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O(2) = (S)- nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O.
  • A cytochrome P450 (heme-thiolate) enzyme found in plants.
  • The enzyme catalyzes an oxidative reaction that does not incorporate oxygen into the product.
  • Forms the methylenedioxy bridge of the protoberberine alkaloid (S)- nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-scoulerine.
  • Cf. EC 1.14.19.65, which catalyzes a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-cheilanthifoline.
  • Formerly EC 1.14.21.12.
 2 B1NF19 Q50LH4
Salutaridine synthase. [EC: 1.14.19.67]
(R)-reticuline + [reduced NADPH--hemoprotein reductase] + O(2) = salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O.
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.
  • Formerly EC 1.1.3.35 and EC 1.14.21.4.
 1 B1NF18
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