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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 127: Cytochrome P450 Cyp124

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Methyl-branched lipid omega-hydroxylase. [EC: 1.14.15.14]
A methyl-branched lipid + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) = an omega-hydroxy-methyl-branched lipid + H(2)O + 2 oxidized ferredoxin [iron-sulfur] cluster.
  • The enzyme, found in pathogenic and nonpathogenic mycobacteria species, actinomycetes, and some proteobacteria, hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate.
 91 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A0H3LC30
(81 more...)
Cholest-4-en-3-one 26-monooxygenase ((25R)-3-oxocholest-4-en-26-oate forming). [EC: 1.14.15.28]
Cholest-4-en-3-one + 6 reduced [2Fe-2S] ferredoxin + 3 O(2) = (25R)-3- oxocholest-4-en-26-oate + 6 oxidized [2Fe-2S] ferredoxin + 4 H(2)O.
  • This cytochrome P450 (heme-thiolate) enzyme, found in several bacterial pathogens, is involved in degradation of the host cholesterol.
  • It catalyzes the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol.
  • The products are exclusively in the (25R) conformation.
  • The enzyme also accepts cholesterol as a substrate.
  • cf. 1.14.15.29.
  • The enzyme can receive electrons from ferredoxin reductase in vitro, its natural electron donor is not known yet.
  • Formerly EC 1.14.13.221.
 91 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A045HBS7 A0A0H3LC30
(81 more...)
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