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CATH Superfamily 1.10.600.10

Farnesyl Diphosphate Synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Farnesyl pyrophosphate synthase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dimethylallyltranstransferase. [EC: 2.5.1.1]
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
  • Will not accept larger prenyl diphosphates as efficient donors.
 21 A0A178UUX8 A0A178UUX8 A0A3L6DNM2 A0A3L6DNM2 A0A3L6DNM2 O24241 P49350 P49353 P49353 P49353
(11 more...)
(2E,6E)-farnesyl diphosphate synthase. [EC: 2.5.1.10]
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate.
  • Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate.
  • The enzyme will not accept larger prenyl diphosphates as efficient donors.
 20 A0A178UUX8 A0A178UUX8 A0A3L6DNM2 A0A3L6DNM2 A0A3L6DNM2 O24241 P49350 P49353 P49353 P49353
(10 more...)
Chrysanthemyl diphosphate synthase. [EC: 2.5.1.67]
2 dimethylallyl diphosphate = diphosphate + chrysanthemyl diphosphate.
  • Chrysanthemyl diphosphate is a monoterpene with a non-head-to-tail linkage; it is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head- to-tail.
  • The mechanism of its formation is similar to that of the early steps of squalene and phytoene biosynthesis.
  • Chrysanthemyl diphosphate is the precursor of chrysanthemic acid, the acid half of the pyrethroid insecticides found in chrysanthemums.
 2 P0C565 Q7XYS8
Lavandulyl diphosphate synthase. [EC: 2.5.1.69]
2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate.
  • Lavandulyl diphosphate is a monoterpene with a non-head-to-tail linkage; it is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head- to-tail.
  • When this enzyme is incubated with dimethylallyl diphosphate and isopentenyl diphosphate, it also forms the regular monoterpene geranyl diphosphate.
  • The enzyme from Artemisia tridentata (big sagebrush) forms both lavandulyl diphosphate and chrysanthemyl diphosphate (see EC 2.5.1.67) when dimethylally diphosphate is the sole substrate.
 1 Q7XYS8
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