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CATH Superfamily 1.10.600.10

Farnesyl Diphosphate Synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: (2Z,6E)-hedycaryol synthase

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
(+)-caryolan-1-ol synthase. [EC: 4.2.1.138]
(+)-beta-caryophyllene + H(2)O = (+)-caryolan-1-ol.
  • A multifunctional enzyme which also forms (+)-beta-caryophyllene from farnesyl diphosphate (EC 4.2.3.89).
  • Formerly EC 3.7.1.15.
 4 A0A2X2P519 A0A2X2P519 B1W019 B1W019
(+)-beta-caryophyllene synthase. [EC: 4.2.3.89]
(2E,6E)-farnesyl diphosphate + H(2)O = (+)-beta-caryophyllene + diphosphate.
  • A multifunctional enzyme which also converts the (+)-beta- caryophyllene to (+)-caryolan-1-ol (see EC 4.2.1.138).
  • Cf. EC 4.2.3.57.
 4 A0A2X2P519 A0A2X2P519 B1W019 B1W019
5-epi-alpha-selinene synthase. [EC: 4.2.3.90]
(2E,6E)-farnesyl diphosphate = 5-epi-alpha-selinene + diphosphate.
  • The enzyme forms 5-epi-alpha-selinene possibly via germecrene A or a 1,6-hydride shift mechanism.
 1 B2J4A4
Pentalenene synthase. [EC: 4.2.3.7]
(2E,6E)-farnesyl diphosphate = pentalenene + diphosphate.
  • Isolated from Streptomyces avermitilis.
  • The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics.
  • The 9si hydrogen of farnesyl diphosphate undergoes a 1,2-hydride shift where it becomes the 1-alpha hydrogen of pentalenene.
  • Formerly EC 4.6.1.5.
 1 Q82IY4
1,8-cineole synthase. [EC: 4.2.3.108]
Geranyl diphosphate + H(2)O = 1,8-cineole + diphosphate.
  • 1,8-cineole is the main product from the enzyme with just traces of other monoterpenoids.
  • The oxygen atom is derived from water.
  • The reaction proceeds via linalyl diphosphate and alpha-terpineol, the stereochemistry of both depends on the organism.
  • However neither intermediate can substitute for geranyl diphosphate.
  • The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)- linalyl diphosphate while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate.
 1 B5GMG2
(2Z,6E)-hedycaryol synthase. [EC: 4.2.3.187]
(2E,6E)-farnesyl diphosphate + H(2)O = (2Z,6E)-hedycaryol + diphosphate.
  • Isolated from the bacterium Kitasatospora setae.
  • The stereochemistry suggests the farnesyl diphosphate rearranges to nerolidyl diphosphate or an equivalent intermediate before cyclization.
  • See also EC 4.2.3.174.
 1 E4MYY0
R-linalool synthase. [EC: 4.2.3.26]
Geranyl diphosphate + H(2)O = (3R)-linalool + diphosphate.
  • Geranyl diphosphate cannot be replaced by isopentenyl diphosphate, dimethylallyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrate.
  • Unlike many other monoterpene synthases, only a single product, (3R)- linalool, is formed.
 1 D5SL78
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