The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Farnesyl-diphosphate farnesyltransferase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P36596 (/IPI) P37268 (/IPI) P37268 (/IPI) P37268 (/IPI) P37268 (/IPI) P37268 (/IPI) P37268 (/IPI)
Farnesyl-diphosphate farnesyltransferase activity GO:0004310
Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.
3 Q02769 (/IMP) Q9HGZ6 (/IMP) Q9HGZ6 (/IMP)
Farnesyl-diphosphate farnesyltransferase activity GO:0004310
Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.
2 P29704 (/IDA) Q02769 (/IDA)
Farnesyl-diphosphate farnesyltransferase activity GO:0004310
Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.
2 Q9HGZ6 (/ISA) Q9HGZ6 (/ISA)
Squalene synthase activity GO:0051996
Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate.
2 Q9HGZ6 (/IMP) Q9HGZ6 (/IMP)
Squalene synthase activity GO:0051996
Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate.
2 Q9HGZ6 (/ISA) Q9HGZ6 (/ISA)
Farnesyl-diphosphate farnesyltransferase activity GO:0004310
Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.
1 P36596 (/IGI)
Farnesyl-diphosphate farnesyltransferase activity GO:0004310
Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.
1 P53798 (/ISO)
Farnesyl-diphosphate farnesyltransferase activity GO:0004310
Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.
1 A0A1D8PI71 (/ISS)
Squalene synthase activity GO:0051996
Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate.
1 P29704 (/IDA)
Squalene synthase activity GO:0051996
Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate.
1 P36596 (/ISS)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
7 P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) Q02769 (/TAS)
Steroid biosynthetic process GO:0006694
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
6 P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
6 P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS)
Regulation of cholesterol biosynthetic process GO:0045540
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
6 P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS)
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
3 P29704 (/IMP) Q9HGZ6 (/IMP) Q9HGZ6 (/IMP)
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
2 Q9HGZ6 (/ISA) Q9HGZ6 (/ISA)
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 Q02769 (/IMP)
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 P53798 (/ISO)
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
1 P36596 (/IGI)
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
1 A0A1D8PI71 (/ISS)
Farnesyl diphosphate metabolic process GO:0045338
The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.
1 Q02769 (/IMP)
Farnesyl diphosphate metabolic process GO:0045338
The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.
1 P53798 (/ISO)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
17 E9PNM1 (/IDA) E9PNM1 (/IDA) E9PNM1 (/IDA) P37268 (/IDA) P37268 (/IDA) P37268 (/IDA) P37268 (/IDA) P37268 (/IDA) P37268 (/IDA) Q57YR9 (/IDA)
(7 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
6 P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS) P37268 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q57YR9 (/IDA) Q57YR9 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
2 Q57YR9 (/IDA) Q57YR9 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 P29704 (/HDA) P36596 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q4Q5W4 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P29704 (/HDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 P29704 (/HDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P36596 (/IGI)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P53798 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 A0A1D8PI71 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 P36596 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A0A1D8PI71 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P29704 (/IDA)
Nuclear outer membrane-endoplasmic reticulum membrane network GO:0042175
The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.
1 P36596 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q02769 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P53798 (/ISO)
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