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CATH Superfamily 1.10.600.10

Farnesyl Diphosphate Synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Octaprenyl diphosphate synthase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
All-trans-octaprenyl-diphosphate synthase. [EC: 2.5.1.90]
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate.
  • This enzyme catalyzes the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate, the isoprenoid side chain of ubiquinone-8 and menaquinone-8.
  • The enzyme adds five isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.
 20735 A0A023Z362 A0A023Z362 A0A023Z362 A0A023Z362 A0A023Z362 A0A023Z362 A0A023Z362 A0A023Z362 A0A023Z362 A0A023Z362
(20725 more...)
Geranylfarnesyl diphosphate synthase. [EC: 2.5.1.81]
Geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)- geranylfarnesyl diphosphate + diphosphate.
  • The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis.
  • It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate.
  • The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate.
  • The enzyme is involved in the biosynthesis of C(25)-C(25) membrane lipids.
  • Formerly EC 2.5.1.n2.
 2 Q3IPL1 Q9UWR6
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