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CATH Superfamily 1.10.600.10

Farnesyl Diphosphate Synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Solanesyl diphosphate synthase 3, chloroplastic/mi...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
All-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific). [EC: 2.5.1.84]
Geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all- trans-nonaprenyl diphosphate.
  • (2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate.
  • The enzyme is involved in the synthesis of the side chain of menaquinone-9.
  • In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation.
  • Formerly EC 2.5.1.11.
 25 A0A0D3GJW4 A0A0D3GJW4 A0A0D3GJW4 A0A0D3GJW4 A0A0D3GJW4 A0A0E0GD44 A0A0E0GD44 A0A0E0GD44 A0A0E0GD44 A0A0E0GD44
(15 more...)
All-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific). [EC: 2.5.1.85]
Geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate.
  • Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate.
  • The plant Arabidopsis thaliana has two different enzymes that catalyze this reaction.
  • SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains.
  • Formerly EC 2.5.1.11.
 4 A0A178VT82 A0A178VT82 Q5HZ00 Q5HZ00
All-trans-decaprenyl-diphosphate synthase. [EC: 2.5.1.91]
(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.
  • This enzyme catalyzes the condensation reactions resulting in the formation of all-trans-decaprenyl diphosphate, the isoprenoid side chain of ubiquinone-10 and menaquinone-10.
  • The enzyme adds seven isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.
 2 O43091 Q54VJ9
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