The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Retinoid X Receptor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: Steroid hormone receptor ERR1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
7 O08580 (/IDA) O08580 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 O08580 (/IPI) O08580 (/IPI) P11474 (/IPI) P11474 (/IPI) P11474 (/IPI) P11474 (/IPI) P11474 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
7 P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) Q5QJV7 (/IDA) Q5QJV7 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 P11474 (/ISA) P11474 (/ISA) P11474 (/ISA) P11474 (/ISA) P11474 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 P11474 (/ISM) P11474 (/ISM) P11474 (/ISM) P11474 (/ISM) P11474 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 P11474 (/NAS) P11474 (/NAS) P11474 (/NAS) P11474 (/NAS) P11474 (/NAS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
5 P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
5 P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
5 P11474 (/IPI) P11474 (/IPI) P11474 (/IPI) P11474 (/IPI) P11474 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
5 O08580 (/ISS) O08580 (/ISS) Q5QJV7 (/ISS) Q5QJV7 (/ISS) Q6QMY5 (/ISS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 Q5QJV7 (/ISS) Q5QJV7 (/ISS) Q6QMY5 (/ISS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
2 O08580 (/IDA) O08580 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 O08580 (/IDA) O08580 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 O08580 (/IDA) O08580 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 O08580 (/IDA) O08580 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 O08580 (/ISO) O08580 (/ISO)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
5 P11474 (/IMP) P11474 (/IMP) P11474 (/IMP) P11474 (/IMP) P11474 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
5 O08580 (/ISS) O08580 (/ISS) Q5QJV7 (/ISS) Q5QJV7 (/ISS) Q6QMY5 (/ISS)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
5 P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
5 P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
5 P11474 (/ISS) P11474 (/ISS) P11474 (/ISS) P11474 (/ISS) P11474 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 O08580 (/IDA) O08580 (/IDA)
Regulation of ossification GO:0030278
Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
2 Q5QJV7 (/IMP) Q5QJV7 (/IMP)
Regulation of ossification GO:0030278
Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
2 O08580 (/ISO) O08580 (/ISO)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
2 Q5QJV7 (/IEP) Q5QJV7 (/IEP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 Q5QJV7 (/IMP) Q5QJV7 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 O08580 (/ISO) O08580 (/ISO)
Regulation of osteoblast differentiation GO:0045667
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
2 Q5QJV7 (/IMP) Q5QJV7 (/IMP)
Regulation of osteoblast differentiation GO:0045667
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
2 O08580 (/ISO) O08580 (/ISO)
Regulation of osteoclast differentiation GO:0045670
Any process that modulates the frequency, rate or extent of osteoclast differentiation.
2 Q5QJV7 (/IMP) Q5QJV7 (/IMP)
Regulation of osteoclast differentiation GO:0045670
Any process that modulates the frequency, rate or extent of osteoclast differentiation.
2 O08580 (/ISO) O08580 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q5QJV7 (/IMP) Q5QJV7 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 O08580 (/ISO) O08580 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O08580 (/IDA) O08580 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O08580 (/IMP) O08580 (/IMP)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
2 Q5QJV7 (/IMP) Q5QJV7 (/IMP)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
2 O08580 (/ISO) O08580 (/ISO)
Positive regulation of cellular response to insulin stimulus GO:1900078
Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.
2 Q5QJV7 (/IMP) Q5QJV7 (/IMP)
Positive regulation of cellular response to insulin stimulus GO:1900078
Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.
2 O08580 (/ISO) O08580 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 O08580 (/IDA) O08580 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA)
(4 more)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
10 P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
10 P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA)
Intercellular bridge GO:0045171
A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
10 P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA) Q569H8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS) P11474 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA) P11474 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 O08580 (/ISS) O08580 (/ISS) Q5QJV7 (/ISS) Q5QJV7 (/ISS) Q6QMY5 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O08580 (/ISO) O08580 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6QMY5 (/ISS)
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