The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 875: Serine/threonine protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
3 A0A1D8PHD2 (/IMP) P06243 (/IMP) P06243 (/IMP)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 P06243 (/IDA) P06243 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P06243 (/IPI) P06243 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P06243 (/IPI) P06243 (/IPI)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Double-strand break repair via break-induced replication GO:0000727
The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
2 P06243 (/IMP) P06243 (/IMP)
Negative regulation of exit from mitosis GO:0001100
Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
2 P06243 (/IPI) P06243 (/IPI)
DNA replication initiation GO:0006270
The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
2 P06243 (/IMP) P06243 (/IMP)
Premeiotic DNA replication GO:0006279
The replication of DNA that precedes meiotic cell division.
2 P06243 (/IMP) P06243 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P06243 (/IDA) P06243 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P06243 (/IGI) P06243 (/IGI)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P06243 (/IMP) P06243 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle GO:0010673
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle.
2 P06243 (/IGI) P06243 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle GO:0010673
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle.
2 P06243 (/IMP) P06243 (/IMP)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
2 P06243 (/IDA) P06243 (/IDA)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
2 P06243 (/IGI) P06243 (/IGI)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
2 P06243 (/IMP) P06243 (/IMP)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
2 P06243 (/IMP) P06243 (/IMP)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
2 P06243 (/IDA) P06243 (/IDA)
Regulation of chromatin silencing at telomere GO:0031938
Any process that affects the rate, extent or location of chromatin silencing at telomeres.
2 P06243 (/IMP) P06243 (/IMP)
Mitotic DNA replication checkpoint GO:0033314
A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
2 P06243 (/IGI) P06243 (/IGI)
Cellular protein-containing complex localization GO:0034629
A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell.
2 P06243 (/IGI) P06243 (/IGI)
Cellular protein-containing complex localization GO:0034629
A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell.
2 P06243 (/IMP) P06243 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 P06243 (/IDA) P06243 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 P06243 (/IMP) P06243 (/IMP)
Positive regulation of meiosis I GO:0060903
Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.
2 P06243 (/IGI) P06243 (/IGI)
Mitotic DNA replication preinitiation complex assembly GO:1902977
Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle.
2 P06243 (/IDA) P06243 (/IDA)
Mitotic DNA replication preinitiation complex assembly GO:1902977
Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle.
2 P06243 (/IMP) P06243 (/IMP)
Positive regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation GO:1904968
Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation.
2 P06243 (/IGI) P06243 (/IGI)
Positive regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation GO:1904968
Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation.
2 P06243 (/IMP) P06243 (/IMP)
Positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination GO:1905263
Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination.
2 P06243 (/IGI) P06243 (/IGI)
Positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination GO:1905263
Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination.
2 P06243 (/IMP) P06243 (/IMP)
Negative regulation of filamentous growth GO:0060258
Any process that decreases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 A0A1D8PHD2 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dbf4-dependent protein kinase complex GO:0031431
A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
3 A0A1D8PHD2 (/IDA) P06243 (/IDA) P06243 (/IDA)
Chromosome, centromeric region GO:0000775
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
2 P06243 (/IDA) P06243 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P06243 (/IDA) P06243 (/IDA)
Dbf4-dependent protein kinase complex GO:0031431
A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2 P06243 (/IGI) P06243 (/IGI)
Dbf4-dependent protein kinase complex GO:0031431
A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2 P06243 (/IPI) P06243 (/IPI)
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