The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transferase(Phosphotransferase) domain 1
".
FunFam 718: casein kinase I
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
4 | P35507 (/IDA) P54367 (/IDA) P54367 (/IDA) P54367 (/IDA) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
3 | P54367 (/TAS) P54367 (/TAS) P54367 (/TAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P54367 (/IPI) P54367 (/IPI) P54367 (/IPI) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
|
3 | P54367 (/IMP) P54367 (/IMP) P54367 (/IMP) |
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
3 | P54367 (/IDA) P54367 (/IDA) P54367 (/IDA) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | P54367 (/IDA) P54367 (/IDA) P54367 (/IDA) |
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
3 | P54367 (/TAS) P54367 (/TAS) P54367 (/TAS) |
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
3 | P54367 (/IDA) P54367 (/IDA) P54367 (/IDA) |
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
3 | P54367 (/IMP) P54367 (/IMP) P54367 (/IMP) |
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
3 | P54367 (/IMP) P54367 (/IMP) P54367 (/IMP) |
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
3 | P54367 (/IMP) P54367 (/IMP) P54367 (/IMP) |
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
|
3 | P54367 (/IMP) P54367 (/IMP) P54367 (/IMP) |
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
3 | P54367 (/IC) P54367 (/IC) P54367 (/IC) |
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
3 | P54367 (/IMP) P54367 (/IMP) P54367 (/IMP) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
1 | P35507 (/IDA) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P54367 (/IDA) P54367 (/IDA) P54367 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | P54367 (/IDA) P54367 (/IDA) P54367 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P54367 (/TAS) P54367 (/TAS) P54367 (/TAS) |
Beta-catenin destruction complex GO:0030877
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
3 | P54367 (/ISS) P54367 (/ISS) P54367 (/ISS) |
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
|
1 | P35507 (/IDA) |